Results 211 to 220 of about 2,876,536 (275)

Association of Urinary pH With Overall Survival in Patients With Stage IV Cancer: A Single‐Center Retrospective Cohort Study

Cancer Nexus, EarlyView.
ABSTRACT Objective This single‐center retrospective cohort study evaluated whether, among patients with stage IV cancer who participated in a pragmatic “alkalization therapy”—defined as a low potential renal acid load diet plus oral sodium bicarbonate and/or potassium/sodium citrate—urinary pH was associated with long‐term survival.
Shion Kachi, Kazuyuki Suzuki, Reo Hamaguchi, Ryoko Narui, Hiromasa Morikawa, Hiromi Wada   +5 more
wiley   +1 more source

The impact of neonatal antibiotic exposure on the development of childhood food allergies. [PDF]

Eur J Pediatr
Ofri M, Kristal E, Cohen B, Beigelman A, Hazan G.   +4 more
europepmc   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Possession of Injectable Epinephrine Among Children with Parent-Reported Food Allergies in Saudi Arabia. [PDF]

J Clin Med
Khojah A, Bukhari A, Alibrahim I, AlSulami M, Alotaibi T, Alotaibi R, Bahareth E, Abulreish I, Alsuruji S, Rajab R, Goronfolah L, Binhussein M, Bulkhi A, Habiballah S, Khojah I.   +14 more
europepmc   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Phenotypes of Food Allergies in Patients with Atopic Dermatitis Aged Under 24 Months: A Multicenter Study. [PDF]

Diagnostics (Basel)
Cogurlu MT, Aydogan M, Cavkaytar O, Uysal P, Culpan HC, Yakici N, Demirkale ZH, Topal E, Yuksel H, Aydemir S, Cigerci Gunaydin N, Aydogmus C, Cekic S, Akkelle E, Tuncel T, Eser Simsek I, Arga M, Altinel ZÜ, Kaplan F, Kiykim A, Suleyman A, Guler N, Yucel E, Cokugras H, Sapan N, Nacaroglu HT, Yasar A, Yesil Y, Hancioglu G, Sancak R, Erdogan MS, Ozdemir O, Ozdemir C, Orhan F.   +33 more
europepmc   +1 more source

How to Optimize Healthy Volunteer Screening and Enrolment in Clinical Trials: A Qualitative and Quantitative Approach to Evaluate Processes and Healthy Volunteers' Perceptions

Clinical Pharmacology &Therapeutics, EarlyView.
Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer, Manuela König, Cathrin J. Vogt, Marina Streckebein, Sybille Baumann, Max Blumenstock, Ruwen Böhm, Fabian Müller, Nadja Struß, Viktoria S. Wurmbach, Antje Blank   +10 more
wiley   +1 more source

"Microbial and immune modulation by 2'-fucosyllactose supplementation during gestation: a strategy to prevent food allergies". [PDF]

Gut Microbes
Brosseau C, Rousseaux A, Le Romancer M, Ropers MH, Lollier V, De Carvalho M, Barbarot S, Bodinier M.   +7 more
europepmc   +1 more source

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV‐1 Latency Reversal

Clinical Pharmacology &Therapeutics, EarlyView.
Romidepsin (RMD), an FDA‐approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency‐reversing activity in vitro but has yielded suboptimal outcomes in kick‐and‐kill HIV‐cure trials when administered as a 5 mg/m2 infusion.
Lauren A. R. Tompkins, Amanda Poliseno, Airlie Ward, Edward P. Browne, Cassandra Gilbert, Craig Sykes, Angela D. M. Kashuba, Mackenzie L. Cottrell   +7 more
wiley   +1 more source

Management of IgE-Mediated Food Allergies in K-12 Schools and Early Childcare Centers. [PDF]

Immunol Allergy Clin North Am
Hoyt AEW, Pappalardo AA, Laubach S, Bingemann TA.   +3 more
europepmc   +1 more source