Results 131 to 140 of about 2,795,805 (398)

Natural Sweetener Stevioside‐Based Dissolving Microneedles Solubilize Minoxidil for the Treatment of Androgenic Alopecia

Advanced Healthcare Materials, EarlyView.
This study addresses limitations of minoxidil (MXD) in treating androgenetic alopecia by using stevioside (STV) as a solubilizing agent and microneedle (MN) material. STV enhanced MXD's solubility and skin absorption, leading to improved drug delivery and significant hair regrowth in animal models, demonstrating strong potential for AGA treatment ...
Junying Zhang, Tianyu Shao, Hailiang Li, Luying Zhu, Lamyaa Albakr, Nial J. Wheate, Lifeng Kang, Chungyong Wu   +7 more
wiley   +1 more source

Modern features of the management of gastrointestinal food allergy in children

Zdorovʹe Rebenka, 2018
Food allergy affects millions of people, reduces the quality of life, can lead to fatal consequences, it is a serious problem for society. Today, much attention is paid to the researches on the development of optimal preventive measures to reduce the ...
Yu.R. Chernysh, O.M. Okhotnikova
doaj   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Microbiota Therapy Acts Via a Regulatory T Cell MyD88/RORγt Pathway to Suppress Food Allergy

Nature Medicine, 2019
The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice.
A. Abdel-Gadir, Emmanuel Stephen-Victor, G. Gerber, Magali Noval Rivas, Sen Wang, Hani Harb, Leighanne Wang, Ning Li, E. Crestani, Sara Spielman, William Secor, Heather Biehl, Nicholas Dibendetto, Xiaoxi Dong, D. Umetsu, L. Bry, R. Rachid, T. Chatila   +17 more
semanticscholar   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Gut microbiota as target for innovative strategies against food allergy. [PDF]

, 2019
The dramatic increase in food allergy prevalence and severity globally requires effective strategies. Food allergy derives from a defect in immune tolerance mechanisms.
Berni, Canani, Bruno, C, Buono, A, Della Gatta, G, Di Scala, C, Ercolini, D., Maddalena, Y, Nocerino, R, Paparo, L, Voto, L   +9 more
core   +1 more source

Managing food allergy: GA2LEN guideline 2022

The World Allergy Organization Journal, 2022
A. Muraro, Debra de Silva, S. Halken, M. Worm, E. Khaleva, S. Arasi, A. Dunn-Galvin, B. Nwaru, N. D. de Jong, P. Rodríguez Del Río, P. Turner, Philip Smith, P. Bégin, E. Angier, H. Arshad, B. Ballmer-Weber, K. Beyer, C. Bindslev‐Jensen, A. Cianferoni, Céline Demoulin, A. Deschildre, M. Ebisawa, M. Fernández-Rivas, A. Fiocchi, B. F. Flokstra-de Blok, J. Gerdts, J. Gradman, K. Grimshaw, Carla Jones, S. Lau, R. Loh, M. Alvaro Lozano, M. Makela, M. Marchisotto, R. Meyer, C. Mills, C. Nilsson, A. Nowak‐Wegrzyn, U. Nurmatov, G. Pajno, M. Podestà, L. Poulsen, H. Sampson, Angel Sanchez, S. Schnadt, H. Szajewska, R. van Ree, C. Venter, B. Vlieg‐Boerstra, A. Warner, G. Wong, Robert J. Wood, T. Zuberbier, G. Roberts, Priya Bansal, R. Berni-Canani, K. Blumchen, A. Bonertz, M. Bourgoin-Heck, Ozlem Ceylon, A. Divaret‐Chauveau, D. Fleischer, Maximiliano R Gómez, M. Groetch, D. Hernández, Betina Hjorth, Lydia Collins Hussey, A. Knulst, A. Leung, D. Mack, V. Mahler, Francesca Mori, L. Namazova-baranova, K. Palosuo, C. Parisi, A. Pastorino, O. Rudzevičienė, M. Said, P. Sawiec, S. Sicherer, Sakura Sato, S. Zubchenko   +81 more
semanticscholar   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children

Allergy, Asthma & Clinical Immunology, 2018
Background Food allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing countries.
Victoria Alejandra Gonzales-González, Adolfo Martin Díaz, Karla Fernández, María Félix Rivera   +3 more
doaj   +1 more source