Results 91 to 100 of about 1,166,475 (305)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Food Insecurity, Population Growth, Urbanization and Water Availability: The Role of Government Stability

open access: yes, 2021
To examine the impact of population growth, urbanization and water availability on food insecurity, this study utilized time series data for the period of 1990–2019, from World Development Indicators (WDI), Food and Agriculture Organization (FAO), and ...
Štefan Bojnec   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Cannibalism among same-aged nymphs of the omnivorous predator Dicyphus errans (Hemiptera: Miridae) is affected by food availability and nymphal density

open access: yesEuropean Journal of Entomology, 2019
Cannibalism, the act of eating an individual of the same species has been little studied in omnivorous insect predators. Dicyphus errans (Wolff) (Hemiptera: Miridae) is a generalist omnivorous predator that commonly occurs in tomato greenhouses and field
Konstantina ARVANITI   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Trends in food availability, 1909–2007 [PDF]

open access: yesThe American Journal of Clinical Nutrition, 2010
The increase in childhood obesity mainly reflects increased energy intake. However, it is not clear which food categories are responsible for this increase. Food availability data, which are calculated from annual food production, imports, beginning stocks, subtracting exports, ending stocks, and nonfood uses, provide clues about which categories are ...
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Agriculture's impacts on water availability

open access: yes, 2015
This report is the output of a working group set up by the Global Food Security programme (GFS), under the auspices of the UK’s Water Research Innovation Partnership (UKWRIP). It explores the tension between the availability of water and the production
Jenkins, Alan   +10 more
core  

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