Results 51 to 60 of about 31,430 (295)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Obesity Science & Practice, 2022 Background Existing research suggests that physical access to food can affect diet quality and thus obesity rates. When defining retail food environment (RFE) quantitatively, there is a little agreement on how to measure “lack of healthy food” and what ...
Elzbieta Titis +2 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Mobilizing Markets: Community Efforts to Decrease Food Insecurity in Meadville, Pennsylvania [PDF]
, 2017 The rural town of Meadville, PA is considered a food desert and issues of food insecurity are a root cause of numerous chronic health problems. In 2014, 26.1% of Meadville residents were living in poverty and nearly 13% have poor nutritional status as a ...
Martin, Kerstin +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Exploring the relationship among food-related values, food-related lifestyle and food-related behavior as lever for changing dietary habits of food desert residents [PDF]
, 2017 The objective of this study is to explore the relationship among food-related values, food-related lifestyle and food-related behavior; to identify the underlying dimensions that summarize and capture the meaning of food-related values; and to segment ...
Thomas, Terrence, Gunden, Cihat
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Is Local Food More Expensive? A Grand Rapids Case Study [PDF]
, 2012 Is locally produced food more expensive than non-locally produced food? As Americans become more aware of how their food is produced and where it is sourced, this question becomes more pertinent. This study compares prices for local fruits and vegetables,
Sauer, Christine
core +1 more source