Results 101 to 110 of about 3,536,825 (286)

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Uncovering the Landscape of Participatory Research in Agricultural Innovation: A Scoping Review

Citizen Science: Theory and Practice
Innovative farming practices to mitigate environmental impacts are critical. Participatory approaches, which actively involve farmers in co-developing solutions, are vital for overcoming resistance and enabling successful, context-specific agricultural ...
Michele Paleologo, Marta Acampora, Serena Barello, Guendalina Graffigna   +3 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

FOOD DELIVERY SERVICES "HUNGRY HUB"

The emergence of digital platforms has revolutionized the food industry, with food delivery services becoming increasingly prevalent worldwide. This paper examines the dynamics, trends, and impacts of food delivery services on consumers, restaurants, and the broader food ecosystem.
Mashamina Rohan, Bhokya Anurag, Dr. K. Sreekala, Mrs. N. Musrat Sultana   +3 more
openaire   +1 more source

united-manufacturing-hub/united-manufacturing-hub: v0.10.6

<h2><a href="https://github.com/united-manufacturing-hub/united-manufacturing-hub/compare/v0.10.5...v0.10.6">0.10.6</a> (2024-01-26)</h2> <h3>Bug Fixes</h3> <ul> <li>added overwrites for last images (<a ...
kruegeralex, Matteo Danelon, Oto.Nak, fossabot, David Mackel, Ferdinand Linnenberg, JonaVo, Ricardo Christmann, Robert Feldmann, actions-user, Lukas Hennies, ONUR CAN KARAMAN, larswitte, Matthew Judijanto, Semantic Release Bot, Pascal Bro, AMINE AMAACH, Derek Tiffany, Arne, Patrick Melichar, chrisproch, felixmhofmann, Jeremy Theocharis   +22 more
core   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Harnessing Pseudomonas spp. for sustainable plant crop protection

Frontiers in Microbiology
This review examines the role of Pseudomonas spp. bacteria as biocontrol agents against crop diseases, focusing on their mechanisms of action, efficacy, and potential applications in sustainable agriculture.
Hussain Alattas, Hussain Alattas, Bernard R. Glick, Daniel V. Murphy, Daniel V. Murphy, Colin Scott, Colin Scott   +6 more
doaj   +1 more source

united-manufacturing-hub/united-manufacturing-hub: v0.13.0

<h1><a href="https://github.com/united-manufacturing-hub/united-manufacturing-hub/compare/v0.12.0...v0.13.0">0.13.0</a> (2024-03-08)</h1> <h3>Bug Fixes</h3> <ul> <li>2038 (<a href="https://github.com ...
kruegeralex, Matteo Danelon, Oto.Nak, fossabot, David Mackel, Ferdinand Linnenberg, JonaVo, Ricardo Christmann, Robert Feldmann, actions-user, Lukas Hennies, ONUR CAN KARAMAN, larswitte, Matthew Judijanto, Semantic Release Bot, Pascal Bro, AMINE AMAACH, Derek Tiffany, Arne, Patrick Melichar, chrisproch, felixmhofmann, Jeremy Theocharis   +22 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin

Biotechnology for Biofuels and Bioproducts
Background Crocetin is a multifunctional apocarotenoid natural product derived from saffron, holding significant promises for protection against various diseases and other nutritional applications.
Tingan Zhou, Young-Kyoung Park, Jing Fu, Piotr Hapeta, Cinzia Klemm, Rodrigo Ledesma-Amaro   +5 more
doaj   +1 more source