Results 71 to 80 of about 1,171,437 (339)

The Hormonal Control of Food Intake

Cell, 2007
Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system. These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas.
Stephen O'Rahilly, Anthony P. Coll, I. Sadaf Farooqi   +2 more
openaire   +3 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Developing fencing policies in dryland ecosystems [PDF]

, 2015
The daily energy requirements of animals are determined by a combination of physical and physiological factors, but food availability may challenge the capacity to meet nutritional needs.
Bashir, S., Becker, M. S., Beudels Jamar, R. C., Blake, S., Boitani, Luigi, Borner, M., Breitenmoser, C., Broekhuis, F., Christianson, D., Cozzi, G., Creel, S., Davenport, T. R. B., Deutsch, J., Dickman, A. J., Dollar, L., Dolrenry, S., Douglas Hamilton, I., Dröge, E., Fitzherbert, E., Foley, C., Hazzah, L., Hilborn, R., Hopcraft, J. G. C., Ikandad,, Jacobson, A., Joubert, B., Joubert, D., Kelly, M. J., Lichtenfeld, L., Mace, G. M., Matandiko, W., Milanzi, J., Mitchell, N., Msuha, M., Mweetwa, T., M’Soka, J., Nyahongo, J., Pettorelli, N., Pimm, S. L., Rosenblatt, E., S. M., Durant, Schenck, C., Schuette, P., Sillero Zubiri, C., Sinclair, A. R. E., Stanley Price, M., Tehou, J. A., Wall, J., Wittemyer, G., Zimmerman, A.   +49 more
core   +2 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

The association between socioeconomic status and adult fast-food consumption in the U.S. [PDF]

, 2017
Health follows a socioeconomic status (SES) gradient in developed countries, with disease prevalence falling as SES rises. This pattern is partially attributed to differences in nutritional intake, with the poor eating the least healthy diets. This paper
Smith, Patricia K., Zagorsky, Jay L.
core   +1 more source

Food Intake and the Role of Food Self-Provisioning [PDF]

The Journal of Development Studies, 2015
This article investigates the role of food self-provisioning for the intake of nutrients of households in Mongolia. We analyse nutritional outcomes within and across urban wage employees, rural households with small herds, and pastoralists with large herds. Food self-provisioning significantly affects dietary quality and quantity.
Lehmann-Uschner, Katharina, Kraehnert, Kati   +1 more
openaire   +5 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Food for Thought: Revisiting the Complexity of Food Intake [PDF]

Cell Metabolism, 2015
The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficulties replicating previously reported
Woods, SC, Begg, DP
openaire   +4 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Glucagon and Neuromedin U Suppress Food Intake in Broiler Chicks

The Journal of Poultry Science, 2015
Several peptides show different effects on food intake between broiler and layer chicks. For example, the central administration of β-melanocyte-stimulating hormone decreased food intake in layer chicks but not in broiler chicks.
Kazuhisa Honda, Takaoki Saneyasu, Mika Okuda, Taku Uemura, Hiroshi Kamisoyama   +4 more
doaj   +1 more source