Results 61 to 70 of about 3,837,045 (265)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Calculation of Compound Intake Levels Using Integrated Food Compound Databases and Food Intake Data

Current Developments in Nutrition
Background: Despite substantial research, the mechanisms through which food influences disease largely remain unclear. Analyzing cohort data at the level of food compounds (i.e.
Marie Y Meima, Joost Westerhout, Sabina Bijlsma, Fiona DM van Schaik, Bas Oldenburg, Marjo JE Campmans-Kuijpers, Marjolein Meijerink, Geert F Houben   +7 more
doaj   +1 more source

Dietary iron intake during early pregnancy and birth outcomes in a cohort of British women [PDF]

, 2011
Background: Iron deficiency during pregnancy is associated with adverse birth outcomes, particularly, if present during early gestation. Iron supplements are widely recommended during pregnancy, but evidence of their benefit in relation to infant ...
Greenwood, Darren C, Godfrey, KM, Simpson, NAB, J. E. Cade, McArdle, Harry J, D. C. Greenwood, Greenwood, Darren C., Alwan, NA, Simpson, Nigel A B, Greenwood, DC, Godfrey, Keith M, H. J. McArdle, McArdle, Harry J., Simpson, Nigel A.B., McArdle, HJ, K. M. Godfrey, Alwan, Nisreen A, Cade, Janet E, Cade, Janet E., Cade, JE, N. A. Alwan, N. A. B. Simpson, Alwan, Nisreen A., Godfrey, Keith M.   +23 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary [PDF]

, 2014
The consumption of specific dairy types may be beneficial for the prevention of diabetes. Abstract: The aim of this study was to investigate the association between total and types of dairy product intake and risk of developing incident type 2 diabetes,
Laura M. O’Connor, Kay-Tee Khaw, Nita G. Forouhi, Robert N. Luben, Marleen A. H. Lentjes, Nicholas J. Wareham   +5 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women [PDF]

, 2002
Objective¿ Phytoestrogens have been postulated to protect against cardiovascular diseases, but few studies have focused on the effect of Western dietary phytoestrogen intake.
Pijpelink, A, Bots, ML (Michiel), Grobbee, D.E., Lamberts, S.W.J., Schouw, Y.T., van der, Peeters, P.H.M., van der Schouw, YT, Bots, M.L., van Staveren, W.A., Peeters, PHM, Pijpe, A., van der Schouw, Y.T., Grobbee, DE, van Staveren, WA, Staveren, W.A., van, Lebrun, CEI (Corinne), Lebrun, C.E.I., JC onderzoeksprogramma Cardiovascular Health, Afdeling Dietetiek, Epidemiology & Health Economics   +19 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source