Results 51 to 60 of about 220,877 (257)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Food restriction decreases thermoregulation in the silky starling Sturnus sericeus (Aves: Passeriformes)

The European Zoological Journal, 2019
The capacity of small birds to sustain periods of food shortage largely depends on their ability to adaptively regulate expenditure in response to reduced food supply.
L.-Y. Mao, J.-Y. Xu, L. Shi, W.-H. Zheng, J.-S. Liu   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A Novel Method for Training Mice in Visuo-Tactile 3-D Object Discrimination and Recognition

Frontiers in Behavioral Neuroscience, 2018
Perceiving, recognizing and remembering 3-dimensional (3-D) objects encountered in the environment has a very high survival value; unsurprisingly, this ability is shared among many animal species, including humans.
Xian Hu, Ogaga Urhie, Kevin Chang, Rachel Hostetler, Ariel Agmon   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The use of animal models to decipher physiological and neurobiological alterations of Anorexia Nervosa patients.

Frontiers in Endocrinology, 2015
Extensive studies were performed to decipher the mechanisms regulating feeding due to the worldwide obesity pandemy and its complications. The data obtained might be adapted to another disorder related to alteration of food intake, the restrictive ...
Mathieu eMéquinion, Christophe eChauveau, Odile eVILTART   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Maternal food restrictions during breastfeeding

Korean Journal of Pediatrics, 2017
This study investigated self-food restriction during breastfeeding, reviewed the literature showing the effect of maternal diet on the health of breast-fed infants, and explored the validity of dietary restrictions.Questionnaire data were collected from breastfeeding Korean mothers who visited the pediatric clinic of Cheil General Hospital & Women's ...
Goun Jeong, Sung Won Park, Yeon Kyung Lee, Sun Young Ko, Son Moon Shin   +4 more
openaire   +3 more sources

Post-hatch fasting and infectious bronchitis vaccination affect growth, gastrointestinal development, and morphometric parameters of the small intestine of broiler breeders up to three weeks of age

Revista Brasileira de Zootecnia
The influence of fasting and vaccination against infectious bronchitis (IB) on growth, gastrointestinal development, and morphometric parameters of the small intestine of newborn broiler breeders was investigated. Weight gain (WG), feed conversion ratio (
Miguel Frederico Fernandez-Alarcon, Fernando Augusto de Souza, Daniel Mendes Borges Campos, Fabricio Hirota Hada, Wedson Carlos Lima Nogueira, Marcos Macari, Luiz Roberto Furlan, Renato Luis Furlan   +7 more
doaj   +1 more source