Results 161 to 170 of about 2,056,712 (313)

Using gender research in development: food security in practice [PDF]

Gender, Development, Research, food security, Household surveys, Food policy, Intrahousehold issues, Decision-making, Research projects, Practitioners, Project management, Women in development, Food supply, Economic development projects,
McClafferty, Bonnie, Quisumbing, Agnes R.   +1 more
core  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Scientists' warning: we must change paradigm for a revolution in toxicology and world food supply. [PDF]

Environ Sci Eur
Seralini GE, Jungers G, Andersen A, Antoniou M, Aschner M, Bacon MH, Bertrand M, Bohn T, Bonfleur ML, Bücking E, Defarge N, Djemil R, Domingo JL, Douzelet J, Fagan J, Fournier T, Garcia JLY, Gil S, Hervé-Gruyer P, Hilbeck A, Hilty L, Huber D, Joyeux H, Khan I, Kouretas D, Lemarchand F, Loening U, Longo G, Mesnage R, Nikolopoulou DI, Panoff JM, Parente C, Robinson C, Scherber C, Sprangers D, Sultan C, Tsatsakis A, Vandelac L, Wan NF, Wynne B, Zaller JG, Zerrad-Saadi A, Zhang X.   +42 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

One Health Approach to Nutritional Status and Well-Being in Food Supply Chain Workers: A Study Protocol. [PDF]

Int J Environ Res Public Health
Siotto M, Cocco C, Bertoncini C, Guerrini A, Habib V, Antonacci E, Ruco E, Aprile IG.   +7 more
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Agri-food supply chain resilience: An exploration of influencing factors based on fuzzy-DEMATEL-ISM analysis. [PDF]

PLoS One
Zhang M, Yang J.
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Food additives in Latin America: a descriptive analysis of the packaged food supply in five countries. [PDF]

Global Health
Zancheta C, Grilo MF, Ayala S, Duran AC, Canella D, Mora M, Abril-Ulloa V, Tolentino-Mayo L, Reyes M, Corvalan C.   +9 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source