Results 51 to 60 of about 433,022 (265)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Demand-Supply Trends and Projections of Food in India [PDF]
The present paper presents the supply and demand trends of rice, wheat, total cereals, pulses, edible oil/oilseeds and sugar/sugarcane. It provides the demand and supply projections for food items during 2011, 2021 and 2026.
Surabhi Mittal
core +1 more source
Assessment of key sustainability indicators in a UK fast food supply chain: a life cycle perspective
, 2012 The purpose of this article is to investigate the understanding of businesses and end consumers of key sustainability measures in the UK fast food Supply Chain.
Nabhani, Farhad +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Can inter-firm networks alleviate supply chain risks within global food supply chains?
, 2009 The food supply chain is truly a global supply chain wherein finished products and raw materials are transported across continents to fulfil requirements of consumers.
Deep, Aman, Dani, Samir
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2021 Reducing anthropogenic carbon emissions and food waste are complex global sustainability challenges that are impacted of and by supply chain activities. This thesis examines structural aspects of the supply chain in relation to sustainable development by
Sundgren, Caroline
core
A Framework for Food Supply Chain Digitalisation: Lessons from Thailand
, 2020 The promise of digitalisation is enormous and nowhere is it more critical than in its potential to transform food supply chain. Consumers have become more educated and are demanding real-time updated information on foods they consumed through digital ...
Tan, Kim Hua +1 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source