Results 71 to 80 of about 61,911 (310)

D-galacto-D-mannan-mediated Dectin-2 activation orchestrates potent cellular and humoral immunity as a viral vaccine adjuvant

Frontiers in Immunology
IntroductionConventional foot-and-mouth disease (FMD) vaccines have been developed to enhance their effectiveness; however, several drawbacks remain, such as slow induction of antibody titers, short-lived immune response, and local side effects at the ...
Hyeong Won Kim, Mi-Kyeong Ko, So Hui Park, Seokwon Shin, Gang Sik Kim, Dong Yun Kwak, Jong-Hyeon Park, Su-Mi Kim, Jong-Soo Lee, Min Ja Lee   +9 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

Disease prevention versus data privacy : using landcover maps to inform spatial epidemic models [PDF]

, 2012
The availability of epidemiological data in the early stages of an outbreak of an infectious disease is vital for modelers to make accurate predictions regarding the likely spread of disease and preferred intervention strategies.
Michael J. Tildesley (123224), Tildesley, Michael J., Ryan Sadie J., Tildesley Michael J., Sadie J Ryan, Ryan, Sadie J., Sadie J. Ryan (24547), Michael J Tildesley   +7 more
core   +1 more source

Evaluation of the Protective Efficacy of Foot-and-Mouth Disease Vaccines Against O/CATHAY Topotype Virus in Pigs

Microorganisms
The world is divided into seven regional pools based on the serotype distribution and geographical spread of the foot-and-mouth disease (FMD) virus. The Republic of Korea (ROK) belongs to Pool 1, where serotypes O, A, and Asia1 are endemic. Recently, the
Ye-Ji Kim, Dong-Wan Kim, Mi-Kyeong Ko, Donghyeon Kim, Seo-Yong Lee, Yerin Kim, Yeonrea Chae, Tae-jun Kim, Hyejin Kim, Min Ja Lee, Sung-Han Park, Jaejo Kim, Jong-Hyeon Park, Ji-Hyeon Hwang, Yoon-Hee Lee   +14 more
doaj   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

The impact of movements and animal density on continental scale cattle disease outbreaks in the United States [PDF]

, 2014
Globalization has increased the potential for the introduction and spread of novel pathogens over large spatial scales necessitating continental-scale disease models to guide emergency preparedness.
Michael J. Tildesley (123224), Miller, Ryan S., Miller, Ryan S.,, Werkman, Marleen,, Buhnerkempe, Michael G.,, Katie Portacci (106341), Grear, Daniel A., Wennergren, Uno,, Lindström, Tom,, Webb, Colleen T.,, Katie Portacci, Keeling, Matt J., Werkman, Marleen, Buhnerkempe, Michael, Colleen T Webb, Lindström, Tom, Jason E. Lombard (543387), Lombard, Jason E., Tom Lindström, Michael J Tildesley, Grear, Daniel A.,, Keeling, Matt J.,, Wennergren, Uno, Colleen T. Webb (106335), Matt J. Keeling (251596), Ryan S. Miller (106337), Tom Lindström (106326), Webb, Colleen T., Marleen Werkman (543388), Portacci, Katie, Lombard, Jason E.,, Keeling, Matthew James, Jason E Lombard, Michael G. Buhnerkempe (212445), Tildesley, Michael J., Daniel A Grear, Daniel A. Grear (106330), Buhnerkempe, Michael G., Marleen Werkman, Portacci, Katie,, Uno Wennergren (106344), Ryan S Miller, Matt J Keeling, Uno Wennergren, Michael G Buhnerkempe, Tildesley, Michael J.,   +45 more
core   +1 more source

THE ETIOLOGY OF FOOT - AND - MOUTH DISEASE. [PDF]

The Lancet, 1886
n ...
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source