Results 51 to 60 of about 12,243,471 (240)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Tibiotalocalcaneal arthrodesis for the treatment of midfoot Charcot neuroarthropathy

Foot & Ankle Surgery: Techniques, Reports & Cases, 2023
Charcot neuroarthropathy of the foot and ankle is a destructive disorder resulting in severe and debilitating deformity. The goal of surgical reconstruction in Charcot neuroarthropathy is to create a stable, plantigrade foot that is amenable to bracing ...
Jacob M. Jones, DPM, Scott D. Schleunes, DPM, John E. Marshall, DPM, Vincent G. Vacketta, DPM, Ryan L. McMillen, DPM, FACFAS   +4 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Foot-and-mouth disease in Tanzania from 2001 to 2006. [PDF]

, 2010
Foot-and-mouth disease (FMD) is endemic in Tanzania, with outbreaks occurring almost each year in different parts of the country. There is now a strong political desire to control animal diseases as part of national poverty alleviation strategies ...
D. Berkvens, Berkvens, D, A. Picado, Kivaria, F., Casal, J, Speybroeck, Niko, Kivaria, F, Picado, A., R. M. Mosha, Picado, A, R. D. Sumaye, J. Casal, Casal, J., Sumaye, R. D., Sumaye, R D, Speybroeck, N., N. Speybroeck, Speybroeck, N, Mosha, R M, Sumaye, RD, Berkvens, D., F. Kivaria, Mosha, R. M., Mosha, RM   +23 more
core   +1 more source

Epidemiology of lameness in prepartum dairy heifers and its association with milk production, reproduction, and diseases in the postpartum period

Journal of Dairy Science
: Lameness directly affects the welfare and productivity of dairy cows, resulting in economic losses. However, little is known about lameness in prepartum dairy heifers.
B.S. Souza, R.R. Daros
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

The impact of rheumatoid arthritis on foot function in the early stages of disease: a clinical case series [PDF]

, 2006
BACKGROUND Foot involvement occurs early in rheumatoid arthritis but the extent to which this impacts on the structure and function leading to impairment and foot related disability is unknown. The purpose of this study was to compare clinical disease
Helliwell, Philip S., Woodburn, James, James Woodburn, Woodburn, J., Paul Emery, Emery Paul, Helliwell Philip S, Turner Deborah E, Turner, D.E., Turner, Deborah E., Deborah E Turner, Helliwell, P.S., Emery, P., Philip S Helliwell, Woodburn James, Emery, Paul   +15 more
core   +2 more sources

Correlating pre-operative MRI measurements of metatarsal Osteomyelitis with surgical clean margins reveals the need for a one centimeter resection margin

Journal of Foot and Ankle Research, 2017
Background Due to the high incidence of forefoot ulcerations with associated osteomyelitis, there has been an increased demand for partial ray amputations.
Brent Bernstein, Melody Stouder, Eric Bronfenbrenner, Steven Chen, David Anderson   +4 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source