Results 91 to 100 of about 81,944 (308)

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Virtually optimized insoles for offloading the diabetic foot: a randomized crossover study [PDF]

, 2017
Integration of objective biomechanical measures of foot function into the design process for insoles has been shown to provide enhanced plantar tissue protection for individuals at-risk of plantar ulceration.
Cavanagh, P.R., Collier, A., Telfer, S., Woodburn, J.   +3 more
core   +1 more source

A “Hot Spring” Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming

Advanced Science, EarlyView.
The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li, Dandan Jin, Fei Li, Jianliang Shen, Jiang Chang, Chen Yang, Shixuan Chen, Yi Zhang   +7 more
wiley   +1 more source

Foot complications among diabetics attending a district hospital in Kenya: Predisposing factors and possible intervention

The Annals of African Surgery, 2008
OBJECTIVES: To relate skin health, footwear practices and foot care education with occurrence of foot complications among diabetics attending a district hospital in Kenya.
M.M. Obimbo, P.K. Bundi, F. Collis
doaj  

Association between sarcopenia and the foot-ankle function in type 2 diabetic foot ulcer

Diabetology & Metabolic Syndrome
Background The diabetic foot (DF) ulcer is the severe complication of type 2 diabetes mellitus (T2DM). Sarcopenia is characterized as the loss of muscle mass and strength, resulting in the increased risk of fracture and physical disability.
Shujing An, Weina Kuang, Yonglu Hu, Xinwei Li, Bingzi Dong, Chengqian Li, Yangang Wang   +6 more
doaj   +1 more source

Hubungan Positif antara Ulkus Kaki Diabetik dengan Persentase Sel Bermarkah Cd4+ Pembawa Malondialdehid [PDF]

, 2009
Tingginya angka kejadian ulkus kaki diabetik (UKD) dan luka di kaki yangsulit sembuh memberi petunjuk kemungkinan ada proses kematian sel imun yangsangat banyak dan belum jelas mekanismenya secara molekuler pada jaringan UKD.Telah diteliti hubungan ...
Mantik Astawa, I Nyoman, Putu SutirtaYasa, I Wayan, Suastika, K. (Ketut), Sudewa Djelantik, Anak AgungGede   +3 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The Effect of Vacuum Compression Therapy on Diabetic Foot ulcer

مجله پژوهش در علوم توانبخشی, 2008
• Background:Recent studies indicate that vacuum compression therapy (VCT) of the foot may offer benefits in patients with intermittent claudication through improving arterial and venous blood flow.
Mojtaba Heshmatipour, Vajiheh Abroshan, Azam Masihi   +2 more
doaj   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types. [PDF]

, 2015
BackgroundComplex wounds present a substantial economic burden on healthcare systems, costing billions of dollars annually in North America alone.
Antony, Jesmin, Cogo, Elise, Hoch, Jeffrey S, Isaranuwatchai, Wanrudee, Khan, Paul A, Sanmugalingham, Geetha, Straus, Sharon E, Tricco, Andrea C   +7 more
core   +3 more sources