Results 101 to 110 of about 81,944 (308)

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Research progress of triglyceride-glucose index with type 2 diabetes mellitus and diabetic foot ulcer

Zhongguo linchuang yanjiu
Diabetic foot ulcer is a serious complication of diabetes mellitus, usually caused by neuropathy and peripheral arterial disease. Studies have shown that insulin resistance is a known risk factor for diabetic foot ulcer.
SHEN Xinyi, LIU Qingyang
doaj   +1 more source

The Missing Link: the key to improved wound assessment [PDF]

, 2012
Clinicians discuss using Debrisoft to improve wound assessement, quality of life and cost ...
Bianchi, Janice, Cook, Leanne, Fumarola, Sian, Ousey, Karen   +3 more
core  

The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination [PDF]

, 2012
Background: Neglected tropical diseases (NTDs) are a group of chronic parasitic diseases and related conditions that are the most common diseases among the 2·7 billion people globally living on less than US$2 per day.
A Alemu, A Aseffa, A Deressa, A Haileamlak, A Yami, Abraham Aseffa, AD Bryceson, Ahmed Ali, AM Dorkenoo, Asrat Hailu, AZ Zein, B Erko, B Erko, B Liese, B Yakob, BA Boatin, C Bogh, C Hanson, C Prasittisuk, C Sikorski, Central Statistical Agency [Ethiopia], ICF International, D Fekadu, DG Addiss, DH Molyneux, DH Molyneux, DR ten Eyck, E Litt, E Negera, E Negera, E Ruiz-Tiben, E Yimer, EW Price, F Demissie, F Tekola, FMOH, FMOH, FMoH, G Davey, G Davey, G Davey, G Mengistu, G Tefera, Gail Davey, GS Smith, H Birrie, H Kloos, H Kloos, J Alvar, J Alvar, JH Kolaczinski, JH Kolaczinski, JO Gyapong, K Bogel, KA Grépin, Kadu Meribo, Kebede Deribe, L Erosie, L Jemaneh, M Fekadu, M Fekadu, M Herrero, MA Brady, MC Baker, Ministry of Health, MJ Burton, MJ Taylor, N Kebede, NB Kabatereine, P Steinmann, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PM Emerson, R ter Horst, RL Pullan, RW Ashford, S Bashaye, S Brooker, S Brooker, S Cairncross, S Negash, SG Gundersen, T Wondimagegnehu, Teshome Gebre, The Carter Center, W Shiferaw, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, Y Berhane, Z Tadesse, ZA Zein   +103 more
core   +2 more sources

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Construction of risk prediction model for recurrence of diabetic foot ulcer

Huli yanjiu, 2022
ObjectiveThis study aimed to investigate the current status and influencing factors of diabetic foot ulcer recurrence within 1 year after healing and to establish a risk prediction model.MethodsThe convenience sampling method was used to select patients ...
LYU Jing, YUAN Li, LI Rao, HUANG Fengmei
doaj  

Association between footwear use and neglected tropical diseases: a systematic review and meta-analysis [PDF]

, 2014
BACKGROUND The control of neglected tropical diseases (NTDs) has primarily focused on preventive chemotherapy and case management. Less attention has been placed on the role of ensuring access to adequate water, sanitation, and hygiene and personal ...
A Alemu, A Liberati, A Martinez Cardenas, A Tremblay, AK Mukerji, B Yakob, BH Singer, BJ Marston, C Bird, CB Leal-Castellanos, CP Douglin, D Ayode, D Humphries, DM Sasaki, E Marion, E Price, EC Strunz, F Portaels, G Davey, G Davey, G Tadesse, Gail Davey, GC Ilechukwu, H Feldmeier, H Kloos, Hannah Clark, HG Lacerda, HO Ejere, I Ali, J Bartram, J Bethony, J Gutman, J Landier, J Lello, J Utzinger, J Utzinger, JC Nmor, Jeffrey Michael Bethony, JM Behnke, JO Alarcon, JZ Killewo, Jürg Utzinger, K Deribe, K Gunawardena, K Modjarrad, K Phiri, K Ziegelbauer, Kebede Deribe, Khizar Rafique, L Erosie, M Albonico, M Muehlen, M Nuti, M Thielecke, M Yunus Khan, MA Johnson, MC Freeman, ME Stocks, MI Gamboa, MR Sulong, N Njau, P Aimpun, P Bovet, P Hotez, P Phraisuwan, P Steinmann, PJ Hotez, PJ Hotez, PL Raghunathan, PM Emerson, PP Yori, PR Sanchez, PW Woodburn, R Anderson, R Kurup, RI Ejemot, RJ Traub, RL Pullan, S Knopp, S Mihrshahi, Sara Tomczyk, Simon J. Brooker, Stefanie Knopp, T Liabsuetrakul, US Ugbomoiko, V Chongsuvivatwong, V Jiraanankul, VJ Lee, WG Smillie, YB Molla, YB Molla   +90 more
core   +4 more sources

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

The Economic Impact of Lower Extremity Amputations in Diabetics. a Retrospective Study From a Tertiary Care Hospital of Faisalabad, Pakistan [PDF]

, 2020
Background: Among the various complications of diabetes, lower-extremity amputation due to diabetic foot is a common problem. In Pakistan, 6-7% of patients with diabetes suffer from diabetic foot ulceration.
Ehsan, S. B. (Sumera), Labeeq, M. (Muhammad), Rehman, W. (Waleed), Tariq, M. A. (Muhammad), Tung, S. A. (Samra), Yar, M. A. (Muhammad)   +5 more
core  

Understanding methods of wound debridement [PDF]

, 2014
Autolytic debridement describes the body's natural method of wound-bed cleansing, helping it to prepare the wound bed for healing. In acute wounds, autolytic debridement occurs automatically and often does not require intervention, as during the ...
Broadus C, Leak K, Ousey K, Ousey K, Strohal R, World Union of Wound Healing Societies (WUWHS)   +5 more
core   +1 more source