Results 51 to 60 of about 222,458 (258)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Cenozoic plate driving forces [PDF]

Geophysical Research Letters, 1995
Past studies of plate driving forces have concluded that the forces due to subducted slabs in the upper mantle and those due to the thickening of the oceanic lithosphere are the principal driving forces. We reexamine the balance of driving forces for the present‐day and extend our analysis through the Cenozoic, using an analytical torque balance method
Lithgow‐Bertelloni, C, Richards, MA
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Plantar Plate Reconstruction for Stage IV Plantar Plate Tear Using Flexor Tendon Tenodesis

Foot & Ankle Orthopaedics, 2018
Category: Lesser Toes Introduction/Purpose: Outcomes of the surgical treatment of dislocated lesser toes have improved significantly over the past few years due to the development of techniques to repair plantar plate tears through a dorsal incision ...
Megan Reilly MD, Kurosh Darvish PhD, Soroush Assari PhD, John Cole BS, Eric Gokcen MD   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A study on the high-speed forming press using electromagnetic force

Advances in Mechanical Engineering, 2017
In this article, a high-speed forming press using electromagnetic pulse force is designed with the finite element analysis. The punch of the press is fixed to an aluminum plate driven by electromagnetic pulse force.
Min Kuk Choi, Chan Gon Park, Young Choi, Ji Yeon Shim, Bong Yong Kang   +4 more
doaj   +1 more source

Validity of load rate estimation using accelerometers during physical activity on an anti-gravity treadmill

Journal of Rehabilitation and Assistive Technologies Engineering, 2021
Introduction A simple tool to estimate loading on the lower limb joints outside a laboratory may be useful for people who suffer from degenerative joint disease.
Susan Nazirizadeh, Maria Stokes, Nigel K Arden, Alexander IJ Forrester   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

On the Driving Forces of Plate Tectonics [PDF]

Geophysical Journal International, 1975
Sumnznry We suppose that the plates are pulled along on top of an effectively viscous asthenosphere by their cold dense sinking leading edges, and that they also tend to slide down the flanks of ocean ridge systems. Using reasonable literature values of density, viscosity and thickness, we find that a typical strong subduction zone pulls about seven ...
openaire   +1 more source

A Comprehensive Study of the Wave Impact Loads on an Inclined Plate

Journal of Marine Science and Engineering, 2019
Water wave impact on a wet deck is an important issue in ocean engineering, and the plate-shaped structure in the splash zone tends to suffer tremendous impact loads.
Zhe Ma, Ting Zhou, Nianxin Ren, Gangjun Zhai   +3 more
doaj   +1 more source