Results 31 to 40 of about 222,458 (258)
Study on neutral axis location of common bolts of flush end-plate connections
Results in Engineering, 2022 The external load eccentricity and the end-plate thickness were employed as the research parameters, and experimental studies on the tensile properties of the bolts with flush end-plate in the beam-column joints was conducted under the action of ...
Anlian Wang +3 more
doaj +1 more source
Stability of Axially Moving Piezolaminated Viscoelastic Plate Subjected to Follower Force
Advances in Materials Science and Engineering, 2015 The stability of the moving viscoelastic plate with the piezoelectric layer subjected to uniformly distributed tangential follower force is investigated.
Yan Wang, Tao Jing, Jimei Wu, Min Xie
doaj +1 more source
Numerical Simulation of Rock Plate Cutting with Three Sides Fixed and One Side Free
Advances in Materials Science and Engineering, 2018 In order to overcome conical pick wear in the traditional rock cutting method, a new cutting method was proposed on account of increasing free surface of the rock.
Zhenguo Lu +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Shock and Vibration, 2023 In order to effectively improve the impact resistance performance of the roadway anti-impact hydraulic support and reduce the loss caused by rock burst to a certain extent, a torsion plate energy-absorbing member was designed for using with the hydraulic
Jianzhuo Zhang +6 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source