Evidence-based severity assessment of the forced swim test in the rat. [PDF]
PLoS ONE, 2023 The forced swim test (FST) is a traditional assay, which has been used for more than 40 years to assess antidepressant effects of novel drug candidates.
Laura Becker +8 more
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Effect of simultaneous testing of two mice in the tail suspension test and forced swim test [PDF]
Scientific Reports, 2022 In mouse studies, the results of behavioural experiments are greatly affected by differences in the experimental environment and handling methods. The Porsolt forced swim test and tail suspension test are widely used to evaluate predictive models of ...
Hiroshi Ueno +6 more
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The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model [PDF]
Open Veterinary JournalBackground: Chronic physical stress has many effects on the nervous system and can cause structural changes in different parts of the brain and hemomodulatory, including hormonal.
Widjiati Widjiati +9 more
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Anxiolytic Effects of Buspirone and MTEP in the Porsolt Forced Swim Test [PDF]
Chronic Stress, 2017 Traditionally, a reduction in floating behavior or immobility in the Porsolt forced swim test is employed as a predictor of anti-depressant efficacy.
Kaziya M Lee +5 more
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The Effect of Propofol on a Forced Swim Test in Mice at 24 Hours [PDF]
Current Therapeutic Research, 2020 : Background: There are few rapidly acting treatments for acute suicidality or treatment-resistant depression. Propofol (2,6-diisopropylphenol) is an intravenous anesthetic agent used in outpatient settings.
David G. Daniel, MD +4 more
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Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test. [PDF]
PLoS ONE, 2019 Major depression is a stress-linked disease with significant morbidity and the anesthetic drug ketamine is of growing interest in the treatment of depression, since in responsive individuals a single dose has rapid (within hours) antidepressant effects ...
Paul J Fitzgerald +2 more
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Sex Differences in the Effects of a Kappa Opioid Receptor Antagonist in the Forced Swim Test [PDF]
Frontiers in Pharmacology, 2018 There is growing evidence that kappa opioid receptor (KOR) antagonists could be a useful class of therapeutics for treating depression and anxiety. However, the overwhelming majority of preclinical investigations examining the behavioral effects of KOR ...
Abigail Laman-Maharg +15 more
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Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats [PDF]
Data in Brief, 2018 Early life adversity, such as neglect, increases the risk for major depressive disorder and anxiety disorders. It is well-known that astrocytes have key roles in brain function.
Yosuke Yamawaki +3 more
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Effect of Various Physical Stress Models on Serum Cortisol Level in Wistar Rats [PDF]
Journal of Clinical and Diagnostic Research, 2014 Background: Stress indicates the response or reaction of an organism to the environmental circumstances and their outcomes. Acute stress is well known to trigger several hormonal alterations in animals. An increase in glucocorticoid concentration can
Mohammed Khaleel Jameel +6 more
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Factors Influencing Behavior in the Forced Swim Test [PDF]
Physiology and Behavior, 2013 Olena V Bogdanova +2 more
exaly +2 more sources