Results 241 to 250 of about 7,358,201 (293)
Some of the next articles are maybe not open access.
Thermoregulatory significance of immobility in the forced swim test
Physiology & Behavior, 2022The forced swim test (FST) is a widely used animal model of depression and antidepressant drug screen. Rats are forced to swim on two test days in a restricted space from which there is no escape. On the first test day the rats attempt to escape and then become largely immobile; on the second test day the onset of immobility is more rapid.
Bryan G, Nadeau +3 more
openaire +2 more sources
Neurobehavioral Studies of Forced Swimming: The Role of Learning and Memory in the Forced Swim Test
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19901. Immobility in the forced swim test ("behavioral despair test") has often been regarded as an animal model of despair or depression. 2. Behavioral studies of forced swimming ("behavioral despair") are reviewed and compared with certain behavioral effects of exposure to inescapable shock (i.e., "learned helplessness"). 3. Exposure to inescapable shock
exaly +3 more sources
Structure of the rat behaviour in the forced swimming test
Behavioural Brain Research, 2005Forced swimming test (FST) or 'behavioural despair' test is a useful screening for antidepressant drugs. The FST predictability has been improved by a number of procedural modifications. Description of the behavioural microstructure in FST may help to delineate innovative protocols.
Cilene, Lino-de-Oliveira +2 more
openaire +2 more sources
Effect of Pilopool on Forced Swimming Test in Mice
International Journal of Neuroscience, 2008Pilopool is composed of high molecular weight water-soluble chitosan, Allium sativum L. extract, mushroom extract, Dioscorea Batatas D., and purple bamboo salt. This study investigated the effect of Pilopool on performance of forced swimming test (FST).
Hyun-Na, Koo +7 more
openaire +2 more sources
A possible alarm substance in the forced swimming test
Physiology & Behavior, 1990Rats were tested in a forced swimming paradigm under a number of conditions which showed that time of day of testing did not significantly affect duration of immobility and a shorter ten-minute test period was as effective as the traditional longer protocol which tests animals 24 hours after initial immersion.
E L, Abel, P J, Bilitzke
openaire +2 more sources
Is Immobility of Rats in the Forced Swim Test “Behavioral Despair?”
Physiology and Behavior, 1988Rats were forced to swim in a cistern until sinking in order to examine the possible relationship between sinking and immobility which has been reported to reflect "behavioral despair" in the forced swim test. Rats were classified into sinking and non-sinking groups, according to the appearance of sinking behavior over a 2 hr test.
Masatoshi Tanaka +2 more
exaly +3 more sources
Effects of antidepressants in the rat forced swimming test
European Journal of Pharmacology, 1981Effects of antidepressants and other drugs on the behaviour of rats in the forced swimming test were examined. Acute and chronic administration of antidepressants reduced the duration of immobility during the first 5 or 10 min of a 30 min test by prolonging escape-directed behaviour which appeared only during this period.
Y, Kitada +3 more
openaire +2 more sources
Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice
The Journal of Pharmacology and Experimental Therapeutics, 2005The influence of dosing time on the anti-immobility effect of antidepressants and mechanisms underlying this phenomenon were investigated in mice. In the forced swimming test (FST), the immobility time of mice treated with amitriptyline (15 mg/kg) and fluvoxamine (30 mg/kg) showed a significant 24-h rhythm.
Kentarou, Ushijima +6 more
openaire +2 more sources
Buspirone enhances immobility in the forced swim test in mice
Pharmacology Biochemistry and Behavior, 1996We studied the effects of buspirone and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on duration of immobility in mice in the forced swim test. Buspirone [3-10 mg/kg, intraperitoneally (IP)] potently and dose dependently increased the duration of immobility in mice.
Y, Kitamura, T, Nagatani
openaire +2 more sources