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Physiological correlates of the forced swim test in rats
Physiology & Behavior, 1993Rats were tested in the forced swim test to evaluate the effects of duration of exposure (0, 5, 15, or 25 min), and water temperature (0, 35, 30, 25, or 20 degrees C), on a variety of physiological measures. Serum corticosterone, glucose, lactate, phosphorus levels, and the anion gap (a measure of acid-base status) were increased significantly, whereas
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Effect of monoamine precursors on the forced-swimming test in mice
Psychopharmacology, 1988The antidepressant properties of monoamine precursors were evaluated by the forced-swimming test for mice developed by Porsolt et al. DOPA but not 5-hydroxytryptophan (5HTP) shortened immobility at doses that did not increase locomotor activity. Although L-threo-dihydroxyphenylserine (DOPS), an artificial norepinephrine (NE) precursor, did not change ...
J I, Semba, R, Takahashi
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Naloxone inhibits clomipramine in mouse forced swimming test
European Journal of Pharmacology, 1982Naloxone inhibited the effect of clomipramine on duration of immobility of mice in the forced swimming test. This test is proposed as an antidepressant study model. It had previously been shown that naloxone inhibited the analgesic effect of the antidepressant clomipramine.
J L, Devoize +3 more
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Pharmacological characterization of the forced swim test in Drosophila melanogaster
Invertebrate Neuroscience, 2020The forced swim test is commonly used as a preclinical screen of antidepressant medication efficacy in rats and mice. Neckameyer and Nieto-Romero (Stress 18:254-66, 2015) adopted the forced swim test for use with the fruit fly Drosophila melanogaster and showed that behavior in this test is sensitive to several physiologically relevant stressors ...
Aryana R. Rasti +3 more
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Ethopharmacology of imipramine in the forced-swimming test: gender differences
Neuroscience & Biobehavioral Reviews, 1998Most of the pre-clinical tests used to assay the efficacy of prospective new agents are done with male experimental animals. In this case, a large part of the population is disregarded as is the interaction of the new agent's effects with female hormonal fluctuations.
H M, Barros, M, Ferigolo
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Gradient of alarm substance in the forced swimming test
Physiology & Behavior, 1991Three studies were conducted with rats to study the effects of a proposed alarm substance released during the forced swimming test. In the first study, rats were retested in water previously swum in but which had been subsequently diluted to varying degrees.
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An automated analysis of rat behavior in the forced swim test
Pharmacology Biochemistry and Behavior, 2001The Porsolt forced swim test (FST) is a commonly used paradigm to evaluate antidepressant activity of drugs. This test is based on visual measurement of the rat's floating time (FT) in a tank filled with water. Here, we present an automated, accurate and faster method for estimating FT by the distance moved (DM) by the animal via the use of the ...
Hédou, Gaël +4 more
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Role of the serotonergic system in the forced swimming test
Neuroscience & Biobehavioral Reviews, 1995The effect of manipulations aimed at modifying the function of the 5-HT system has been reviewed. 5-HT uptake inhibitors are devoid of any activity in rats and induce an anti-immobility effect in mice. The so-called 5-HT1A agonists reduce the immobility time with some differences in mice and rats, mice being less sensitive.
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Omega-3 fatty acids on the forced-swimming test
Journal of Psychiatric Research, 2008Based on the findings of epidemiological data and recent clinical trials, omega-3 fatty acids seem to have a preventive and therapeutic effect on depression.We examined the effect of omega-3 fatty acids on the forced-swimming test (FST) in two groups of Sprague-Dawley rats after a six-week treatment with two different diets.
Huang, S Y +4 more
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Role of corticotropin-releasing factor in forced swimming test
European Journal of Pharmacology, 1998Several aspects of the role of corticotropin-releasing factor (CRF) in the forced swimming test were investigated in this study by using two different administration schedules. I.c.v. microinjection of CRF produced a dose-dependent increase in swimming activity when the administration schedule originally reported for this test to screen antidepressant ...
C, García-Lecumberri, E, Ambrosio
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