Results 261 to 270 of about 7,358,201 (293)
Some of the next articles are maybe not open access.
Forced swimming test in mice: a review of antidepressant activity
Psychopharmacology, 2004Among all animal models, the forced swimming test (FST) remains one of the most used tools for screening antidepressants.This paper reviews some of the main aspects of the FST in mice. Most of the sensitivity and variability factors that were assessed on the FST are summarized.We have summarized data found in the literature of antidepressant effects on
Benoit, Petit-Demouliere +2 more
openaire +2 more sources
On the role of endogenous GABA in the forced swimming test in rats
Pharmacology Biochemistry and Behavior, 1988GABA content was reduced in the nucleus accumbens, cortex and brainstem of rats after 5 but not after 45, 120 min or 24 hr, from the termination of the pretest session. This reduction was not observed in rats performing on rotarod. Intraperitoneal AOAA (25 mg/kg; 24, 5 and 1 hr before the test), reduced at the same extent immobility time regardless ...
F, Borsini +4 more
openaire +2 more sources
Effects of anxiogenic drugs in rat forced swimming test
Methods and Findings in Experimental and Clinical Pharmacology, 1999The effect of antidepressants and anxiogenics in the forced swimming (Porsolt') test was investigated in rats. On the second day of an experiment, desipramine (10 mg/kg), pentylenetetrazole (20 mg/kg), picrotoxin (2.5 mg/kg), and clonidine (1.0 mg/kg) shortened while buspirone (1.0 mg/kg), yohimbine (2.5 mg/kg), DMCM (1.0 mg/kg), and Ro-15-4513 (1.0 mg/
T, Skrebuhhova, L, Allikmets, V, Matto
openaire +2 more sources
The Forced Swim Test for Depression-Like Behavior in Rodents
2018The forced swim test assesses learned helplessness, which is a feature of depression-like behavior in rodents. This test has also been used in testing the efficacy of existing and novel antidepressant drugs. It is based on the natural tendency of rodents to escape from water.
Kraeuter, Ann-Katrin +2 more
openaire +2 more sources
Automated analysis of antidepressants’ effect in the forced swim test
Journal of Neuroscience Methods, 2010The forced swim test (FST) is a commonly used procedure of preclinical screening of drugs for the antidepressant activity. It has high predictive validity for a large group of antidepressant drugs blocking serotonin and noradrenaline reuptakes and improvement of immobility time evaluation in the FST is an important problem of preclinical ...
Alexander V, Kulikov +4 more
openaire +2 more sources
Behavioral effect of herbal glycoside in the forced swimming test
Methods and Findings in Experimental and Clinical Pharmacology, 2002We investigated the behavioral effects of Chinese herbal medicines in the forced swimming test. One of these medicines, Kami-shoyo-san, induced an antidepressive climbing behavior in mice. An effective substance detected to be an O-linked glycoside with the sugar chain structure GalNAc alpha 1-3GalNAc was separated.
Y, Masuda +4 more
openaire +2 more sources
Antidepressant-like effects of selegiline in the forced swim test
European Neuropsychopharmacology, 2005Although selegiline, a monoamine oxidase (MAO)-B inhibitor, is reported to exert antidepressant effects in depressant patients, evidence in rodents for effects of selegiline is quite limited. The purpose of the present study was to assess effects of selegiline in the forced swim test (FST) and on locomotor activity, and to investigate whether MAO ...
Seiichiro, Shimazu +3 more
openaire +2 more sources
Effect of Forced Swimming on the Performance of the “Water Escape Test”
Journal of Evolutionary Biochemistry and PhysiologyHousing conditions and prior life experiences can influence, to varying degrees, animal behavior, brain regions that regulate important neural and physiological functions such as memory, stress responses, and emotional behavior. Stressors of low to moderate intensity, occurring in enriched environments and training, promote the development and ...
M. A. Tur, I. V. Belozertseva
openaire +1 more source
Estimate of the effect of antidepressants in the forced swimming test
Optoelectronics, Instrumentation and Data Processing, 2009Justification and experimental verification of the computer vision algorithm and the maximum likelihood method for automatic estimation of the time of animal immobility in the forced swimming test are given. The computer vision algorithm is based on studying the difference between the frames with the animal images.
V. A. Kulikov +3 more
openaire +1 more source