Results 81 to 90 of about 131,423 (262)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
“Rhythm in the Force of Forces”
Critical Times, 2019 Abstract This essay is addressed to discrepancies between musical and political time. It uses the death of Hugh Masekela to consider the changing pattern of intergenerational relationships and the place of music within local and transnational freedom movements.
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Silver nanoparticles preplant bulb soaking affects tulip production
Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2019 Nanomaterials and particularly silver nanoparticles (AgNPs) have increased great interest in many fields of science. The element may affect plant growth and development but so far research studies have been scarce and their results disparate.
Andżelika Byczyńska +2 more
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Maximum Oriented Forcing Number for Complete Graphs
Theory and Applications of Graphs, 2019 The \emph{maximum oriented $k$-forcing number} of a simple graph $G$, written $\MOF_k(G)$, is the maximum \emph{directed $k$-forcing number} among all orientations of $G$.
Yair Caro, Ryan Pepper
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On the Terms “Centrifugal Force” and “Force of Inertia” [PDF]
Nature, 1892 THE retention, in the last edition of Mr. Loney's “Elements of Dynamics,” 1891, of a paragraph (p. 141) which resuscitates the objections formerly urged by some writers against the use of the term “centrifugal force” seems to call for a protest. It is to be regretted that students of dynamics should find absolutely contradictory statements presented to
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FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source