Results 91 to 100 of about 251,793 (312)

Jensen ${\Delta }_n^1$ Reals by Means of ZFC and Second-Order Peano Arithmetic

Axioms
It was established by Jensen in 1970 that there is a generic extension L[a] of the constructible universe L by a non-constructible real a∉L, minimal over L, such that a is Δ31 in L[a].
Vladimir Kanovei, Vassily Lyubetsky
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Major factors influencing local dust radiative forcing

, 2008
In conclusion, it is shown in this paper that surface albedo variations over desert regions can have a significant influence on the solar and net radiative forcing of desert dust.
Otto, Sebastian, Bierwirth, Eike, Bauer, Stefan, Trautmann, Thomas, Wendisch, Manfred   +4 more
core  

Antarctic ice sheet and oceanographic response to eccentricity forcing during the early Miocene [PDF]

, 2011
Stable isotope records of benthic foraminifera from ODP Site 1264 in the southeastern Atlantic Ocean are presented which resolve the latest Oligocene to early Miocene (~24–19 Ma) climate changes at high temporal resolution (<3 kyr).
van de Wal, R.S.W., H. Pälike, Pälike, H., Hodell, D. A., de Boer, B., Lourens, L.J., Lourens, L. J., D. Liebrand, B. de Boer, Wal, R.S.W. van de, L. J. Lourens, De Boer, B.; id_orcid, Hodell, D.A., van de Wal, R. S. W., Liebrand, Diederik, Van De Wal, R. S.W., R. S. W. van de Wal, D. A. Hodell, Liebrand, D., Boer, B. de   +19 more
core   +1 more source

The Fifth Force, the Sixth Force and the Spring Force

Applied Physics Research, 2012
Upon  revisiting the famous Pound-Rebka-Snider experiments on the gravitational red-shift , the fifth and even the sixth force in nature are in fact the stretching and compression force of the spring , where the spring term is the cosmological constant in Einstein’s field equations.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Topology and models of ZFC at early Universe

Zagadnienia Filozoficzne w Nauce, 2019
Recently the cosmological evolution of the universe has been considered where 3-dimensional spatial topology undergone drastic changes. The process can explain, among others, the observed smallness of the neutrino masses and the speed of inflation ...
Jerzy Król, Torsten Asselmeyer-Maluga
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Why radiative forcing might fail as a predictor of climate change

, 2005
Radiative forcing has been widely used as a metric of climate change, i.e. as a measure by which various contributors to a net surface temperature change can be quantitatively compared.
Ponater, M., Sausen, R., Stuber, N.
core   +1 more source