Results 101 to 110 of about 251,793 (312)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Atmospheric impact of the 1783-1784 Laki Eruption: Part II - Climatic effect of sulphate aerosol [PDF]

, 2003
The long 1783-1784 eruption of Laki in southern Iceland, was one of the first eruptions to have been linked to an observed climate anomaly, having been held responsible for cold temperatures over much of the Northern Hemisphere in the period 1783-1785.
Highwood, E. J., Stevenson, D.S., Stevenson, D. S.; id_orcid, Stevenson, D. S., D. S. Stevenson, E.-J. Highwood, Highwood, E.J., Highwood, E.-J.   +7 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

The shortwave to longwave ratio in contrail radiative forcing as evident in two radiation schemes used for global GCMs

, 2013
Contrail radiative forcing is difficult to obtain, even if contrail parameters like coverage, ice water content, crystal size etc. are known. Respective results as documented in literature hint to a substantial uncertainty.
Bock, Lisa, Ponater, Michael, Dietmüller, Simone, Frömming, Christine   +3 more
core  

Environmental forcing, invasion and control of ecological and epidemiological systems [PDF]

, 2007
Destabilising a biological system through periodic or stochastic forcing can lead to significant changes in system behaviour. Forcing can bring about coexistence when previously there was exclusion, it can excite massive system response through resonance,
Norman, Rachel, Greenman, Jonathan
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Total Forcing Sets and Zero Forcing Sets in Trees

Discussiones Mathematicae Graph Theory, 2020
A dynamic coloring of the vertices of a graph G starts with an initial subset S of colored vertices, with all remaining vertices being non-colored. At each discrete time interval, a colored vertex with exactly one non-colored neighbor forces this non ...
Davila Randy, Henning Michael A.
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Small influence of solar variability on climate over the past millennium

, 2014
The climate of the past millennium was marked by substantial decadal and centennial scale variability in the Northern Hemisphere(1). Low solar activity has been linked to cooling during the Little Ice Age (AD 1450-1850; ref.
Hegerl, Gabriele C., Tett, Simon F. B., Schurer, Andrew P., Simon F. B. Tett, Gabriele C. Hegerl, Andrew P. Schurer   +5 more
core   +1 more source

The impact of air pollutant and methane emission controls on tropospheric ozone and radiative forcing: CTM calculations for the period 1990-2030 [PDF]

, 2004
To explore the relationship between tropospheric ozone and radiative forcing with changing emissions, we compiled two sets of global scenarios for the emissions of the ozone precursors methane (CH4), carbon monoxide (CO), non-methane volatile organic ...
F. Dentener, D. Stevenson, Bergamaschi, P., Mechler, R., Stevenson, D.; id_orcid, Raes, F., F. Raes, Dentener, F., R. Mechler, M. Amann, Derwent, R., Stevenson, D.S., P. Bergamaschi, R. Derwent, Cofala, J., Stevenson, D., J. Cofala, Amann, M.   +17 more
core   +1 more source