Results 121 to 130 of about 316,009 (304)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Environmental forcing, invasion and control of ecological and epidemiological systems [PDF]
, 2007 Destabilising a biological system through periodic or stochastic forcing can lead to significant changes in system behaviour. Forcing can bring about coexistence when previously there was exclusion, it can excite massive system response through resonance,
Norman, Rachel, Greenman, Jonathan
core +1 more source
Silver nanoparticles preplant bulb soaking affects tulip production
Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2019 Nanomaterials and particularly silver nanoparticles (AgNPs) have increased great interest in many fields of science. The element may affect plant growth and development but so far research studies have been scarce and their results disparate.
Andżelika Byczyńska +2 more
doaj +1 more source
Maximum Oriented Forcing Number for Complete Graphs
Theory and Applications of Graphs, 2019 The \emph{maximum oriented $k$-forcing number} of a simple graph $G$, written $\MOF_k(G)$, is the maximum \emph{directed $k$-forcing number} among all orientations of $G$.
Yair Caro, Ryan Pepper
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Determination of a lower bound on Earth's climate sensitivity
Tellus: Series B, Chemical and Physical Meteorology, 2013 Transient and equilibrium sensitivity of Earth's climate has been calculated using global temperature, forcing and heating rate data for the period 1970–2010.
STEPHEN E. Schwartz, LENNART Bengtsson
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Life force and death force in Life force and death force in
Ilha do Desterro, 2008 Frieda Lawrence first introduced her husband to the work of Sigmund Freud when the last draft of Sons and Lovers was being finished. That's why critics, even now, wonder about the extent of the influence Fredian theories might have had upon the novel.
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source