Results 91 to 100 of about 185,793 (320)
Neuromodulatory control of localized dendritic spiking in critical period cortex. [PDF]
, 2019 Sensory experience in early postnatal life, during so-called critical periods, restructures neural circuitry to enhance information processing1. Why the cortex is susceptible to sensory instruction in early life and why this susceptibility wanes with age
Ringach, Dario L +2 more
core
Animal Models and Experimental Medicine, EarlyView.The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo +8 more
wiley +1 more source
A continuum model for the dynamics of the phase transition from slow-wave sleep to REM sleep [PDF]
, 2010 Previous studies have shown that activated cortical states (awake and rapid eye-movement (REM) sleep), are associated with increased cholinergic input into the cerebral cortex.
Li, Xiaoli +5 more
core +2 more sources
Annals of Neurology, EarlyView.Objective Behavior and motor manifestations are distinctive yet often overlooked features of epileptic seizures. Seizures can result in transient disruptions in motor control, often organized into specific behavioral sequences that can inform seizure types, onset zones, and outcomes.
Yuyan Shen +8 more
wiley +1 more source
Dopamine Systems in the Forebrain [PDF]
, 2009 The brain contains a number of distinct regions that share expression ofdopamine (DA) and its requisite biosynthetic machinery, but otherwise encompass a diverse array of features and functions. Across the vertebrate family, the olfactory bulb (OB) contains the major DA system in the forebrain. OB DA cells are primarily periglomerular interneurons that
John W, Cave, Harriet, Baker
openaire +2 more sources
Annals of Neurology, EarlyView.Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos +34 more
wiley +1 more source
Anatomical Progression of Neuropathology in FTLD‐TDP Type C and Linkage to Annexin A11
Annals of Neurology, EarlyView.Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Allegra Kawles +7 more
wiley +1 more source
Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. [PDF]
, 2010 Signaling mechanisms mediated by the Transforming Growth Factor-beta (TGF-beta) superfamily regulate a variety of developmental processes. Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-beta/activin ...
Lee, Amie Y +4 more
core
Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. [PDF]
, 2014 BackgroundThe genetic programs required for development of the cerebral cortex are under intense investigation. However, non-coding DNA elements that control the expression of developmentally important genes remain poorly defined. Here we investigate the
Chen, Bin +8 more
core +4 more sources
Annals of Neurology, EarlyView.Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang +7 more
wiley +1 more source