Results 231 to 240 of about 185,793 (320)

CRISPR‐Cas9‐Generated TXNDC15 c.560delA Homozygous Mouse Model Exhibits Meckel–Gruber Syndrome Phenotype

genesis, Volume 64, Issue 1, February 2026.
ABSTRACT To determine whether TXNDC15 variation causes Meckel–Gruber syndrome (MKS), we assessed the pathogenicity of the frameshift variant c.560delA. A CRISPR–Cas9 generated mouse model carrying the equivalent Txndc15 c.512delA mutation was analyzed at embryonic day 15.5.
Yang Liu, Hui Wang, Liyuan Chen, Xiaoxia Wu, Zhiyong Xu, Qingfa Huang, Hu Zhang, Xiushu Cao, Xinyuan Liang, Xingjian Zhong, Caiqun Luo   +10 more
wiley   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway

, 2018
Haiping Dong, Zhou Wang, Xiaoxiao Ma, Z. He, Z.H. Wang   +4 more
openalex   +1 more source

The Ontogenetic Development of Rapid Eye Movement Sleep in Early Life and Its Regulatory Mechanisms

International Journal of Developmental Neuroscience, Volume 86, Issue 1, February 2026.
REM sleep was first identified in humans and cats in the late 1950s and exhibits a conserved developmental trajectory across species. This study elucidates key characteristic changes during REM sleep development, thereby providing a foundation for improving the prevention and treatment of various neurodevelopmental disorders.
Xiu‐Juan Zhang, Xu‐Hao Gao, An‐Hong Wang, Cai‐Qin Wang, Jia Liu, Yan‐Li Hu, Bo‐Wen Duan, Hai‐Yun Huang, Jin‐Xian Gao   +8 more
wiley   +1 more source

The Sense of Smell (SoS) Atlas: Its Creation and First Application to Investigate COVID‐19 Related Anosmia With a Comprehensive Quantitative MRI Protocol

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 574-593, February 2026.
ABSTRACT Background The loss of smell (anosmia) has been noted in numerous diseases, including COVID‐19. Inflammatory and microstructural alterations are possible underlying mechanisms of anosmia in COVID‐19. However, no atlas exists to study olfaction and the associated tissue property changes.
Marta Gaviraghi, Eleonora Lupi, Elena Grosso, Andrea Fusari, Mattia Baiguera, Anita Monteverdi, Marco Battiston, Francesco Grussu, Baris Kanber, Ferran Prados Carrasco, Rebecca S. Samson, Janine Makaronidis, Marios C. Yiannakas, Michael S. Zandi, Rachel L. Batterham, Egidio D'Angelo, Fulvia Palesi, Claudia A. M. Gandini Wheeler‐Kingshott   +17 more
wiley   +1 more source

Cholinergic basal forebrain degeneration in isolated REM sleep behaviour disorder. [PDF]

Brain
Kim R, Jin B, Kim H, Woo KA, Yoon EJ, Kim S, Shin JH, Nam H, Kim YK, Jeon B, Lee JY.   +10 more
europepmc   +1 more source

Frequency‐Dependent Diffusion–Relaxation Distribution MRI: Scan–Rescan Reproducibility Ex Vivo and Caveats

NMR in Biomedicine, Volume 39, Issue 2, February 2026.
Frequency‐dependent multidimensional (ωMD) diffusion‐relaxation MRI captures microstructural information beyond conventional voxel‐averaged metrics. Here, we evaluate ωMD‐MRI reproducibility in ex vivo mouse brains using a high‐performance micro‐imaging system.
Pak Shing Kenneth Or, Maxime Yon, Omar Narvaez, Eppu Manninen, Tarja Malm, Alejandra Sierra, Daniel Topgaard, Dan Benjamini   +7 more
wiley   +1 more source

Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study. [PDF]

Alzheimers Dement
Russell JK, Schlachetzki Z, Conley AC, Boyd BD, Newhouse PA, Aisen PS, Rafii MS, Alzheimer's Biomarker Consortium on Down Syndrome Study.   +7 more
europepmc   +1 more source

Medial Forebrain Bundle [PDF]

, 2020
openaire   +1 more source

Dropped jaw as a feature of suspected nutritional encephalopathy in a cat

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 3‐year‐1‐month‐old female neutered domestic shorthair cat was presented for reluctance to jump over 3 months. Neurological and orthopaedic examinations, laboratory tests and cerebrospinal fluid analysis were unremarkable. Magnetic resonance imaging revealed mild bilateral symmetrical intra‐axial changes in the caudal brainstem.
Eleftheria Skovola, Oliver Williams, Serena Maini, Abbe Crawford   +3 more
wiley   +1 more source