Results 81 to 90 of about 63,434 (349)

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Forelimb Motor Skills Deficits Following Thoracic Spinal Cord Injury: Underlying Dopaminergic and Neural Oscillatory Changes in Rat Primary Motor Cortex

ASN Neuro, 2021
The loss of spinal sensorimotor pathways following spinal cord injury (SCI) can induce retrograde neurodegeneration in the primary motor cortex (M1). However, the effect of thoracic SCI on forelimb motor skills has not been studied clearly. So, herein we
Omid Salimi, Hamid Soltani Zangbar, Soheila Hajizadeh Shadiabad, Meysam Ghorbani, Tahereh Ghadiri, Abbas Ebrahimi Kalan, Hasan Kheyrkhah, Parviz Shahabi   +7 more
doaj   +1 more source

Bat Accelerated Regions Identify a Bat Forelimb Specific Enhancer in the HoxD Locus

bioRxiv, 2015
The molecular events leading to the development of the bat wing remain largely unknown, and are thought to be caused, in part, by changes in gene expression during limb development.
B. M. Booker, Tara Friedrich, Mandy K. Mason, J. Vandermeer, Jingjing Zhao, W. Eckalbar, M. Logan, N. Illing, K. Pollard, N. Ahituv   +9 more
semanticscholar   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Establishing Joint Orientation Angles of the Limbs in Korean Raccoon Dogs (Nyctereutes procyonoides koreensis) Using Computed Tomographic Imaging

Animals
Studies are being conducted on the anatomical structures of various wild animals. Despite the ecological importance of the Korean raccoon dog (Nyctereutes procyonoides koreensis), limited research has been conducted on its anatomical structure.
Seongju Ko, Sangjin Ahn, Ho-Hyun Kwak, Heung-Myong Woo, Junhyung Kim   +4 more
doaj   +1 more source

FORELIMB MALFORMATION IN RATS CAUSED BY CYCLOPHOSPHAMIDE [PDF]

Journal of Pediatric Orthopaedics, 1984
A single dose of cyclophosphamide (20 mg/kg) was administered to female rats on Day 12 of gestation. Fetuses were collected at 24-h intervals from gestation Day 18 to 20. Gross malformations of the forelimb were observed, notably micromelia, oligodactyly, brachydactyly and adactyly.
N, Jeyaseelan, S, Singh
openaire   +2 more sources

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats

Journal of Experimental Neuroscience, 2019
This study examines and compares the walking function in contusion and distraction spinal cord injury (SCI) mechanisms. Moderate contusion and distraction SCIs were surgically induced between C5 and C6 in Sprague-Dawley male rats.
Yue Guo, Hai Hu, Jingchao Wang, Meiyan Zhang, Kinon Chen   +4 more
doaj   +1 more source

Suppression of activity in the forelimb motor cortex temporarily enlarges forelimb representation in the homotopic cortex in adult rats.

, 2008
After forelimb motor cortex (FMC) damage, the unaffected homotopic motor cortex showed plastic changes. The present experiments were designed to clarify the electrophysiological nature of these interhemispheric effects.
MAGGIOLINI, Emma, FRANCHI, Gianfranco, VIARO, Riccardo   +2 more
core   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source