Results 101 to 110 of about 85,948 (287)

Examining Phosphatidylethanol (PEth) Formation Rates Within and Between Subjects in Ex Vivo Whole Blood

Drug Testing and Analysis, EarlyView.
PEth formation rate increased with increasing ethanol concentration with variability between participants but was mostly consistent within‐subject. No relationship was observed between phosphatidylcholine concentrations and PEth formation rates. PEth concentrations should be used to monitor an individual's ethanol use over time, rather than compared ...
Haidyn G. Stark, Jesus J. Sanchez, Nathalie Hill‐Kapturczak, John D. Roache, Brett C. Ginsburg   +4 more
wiley   +1 more source

Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury

Cell Death Discovery
Skeletal muscle repair after injury requires coordinated immune responses. The cannabinoid type 2 receptor (CB2R) has been implicated in this process; however, its molecular mechanism in regulating inflammation and muscle regeneration, particularly ...
Xinjie Li, Haomiao Yuan, Shuyang Mu, Jiaqing Pan, Fuyuan Zhang, Shukui Du, Jin Liu, Anran Qu, Yingfu Sun, Linlin Wang, Ping Huang, Rui Zhao, Dawei Guan   +12 more
doaj   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose

Drug Testing and Analysis, EarlyView.
A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek, Marie Katrine Klose Nielsen, Robert Kronstrand, Sys Stybe Johansen   +3 more
wiley   +1 more source

Innovative Development and Future Prospects in Forensic Pathology

Fayixue Zazhi
As a discipline with a long history, forensic pathology is tasked with determining the cause of death, clarifying the nature and manner of death, and reconstructing the truth of events based on postmortem examinations.
LIU Ning-guo
doaj   +1 more source

Determination of THC and THC‐COOH in Dried Capillary Blood Spots and Comparison to Venous Blood of Recreational Cannabis Consumers in a Pilot Study

Drug Testing and Analysis, EarlyView.
A new extraction method was developed and validated for the extraction of THC and THC‐COOH from capillary blood samples collected as dried blood spots. The extracts were analysed using HPLC–MS/MS resulting in high extraction efficiencies for both THC and THC‐COOH.
Matthias Bantle, Willi Schirmer, Joel Bruegger, Thomas Wüthrich, Andreas Längin, Lena Zwicker, Reto Auer, Wolfgang Weinmann   +7 more
wiley   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

The need for informatics to support forensic pathology and death investigation

Journal of Pathology Informatics, 2015
As a result of their practice of medicine, forensic pathologists create a wealth of data regarding the causes of and reasons for sudden, unexpected or violent deaths.
Bruce Levy
doaj   +1 more source

Comparison of Dried Blood Spot Sampling Methods for RNA‐Based Biomarker Measurement in Anti‐Doping

Drug Testing and Analysis, EarlyView.
This study demonstrates that RNA‐based biomarkers of erythropoiesis, ALAS2 and CA1, can be reliably quantified across commonly used DBS sampling matrices, including venous and capillary blood spotted on cellulose cards and the Tasso‐M20 device. ABSTRACT Dried blood spot (DBS) sampling offers logistical advantages, but it remains unexplored whether ...
Jacob Bejder, Corentin Schlechten, Claudia Mumenthaler, Olivier Salamin, Tiia Kuuranne, Thomas Christian Bonne, Jonathan Graae, Henrik Sørensen, Nikolai B. Nordsborg, Nicolas Leuenberger   +9 more
wiley   +1 more source

Elimination Profile of Deflazacort and Metabolites in Urine and Plasma Following Oral Administration: Relevance to Sports Drug Testing

Drug Testing and Analysis, EarlyView.
Results confirm that the MRL of 30 ng/mL for 21‐desacetyl‐deflazacort together with a 3‐day washout period is an appropriated strategy to detect oral deflazacort administration in sport competition. ABSTRACT Deflazacort (DEF) is a glucocorticoid prohibited in sports competitions when orally administered.
Sergi Coll, Claudia Bressan, Núria Monfort, Ana Aldea‐Perona, Marcel·lí Carbó, Rosa Ventura   +5 more
wiley   +1 more source