Results 101 to 110 of about 120,573 (301)

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Understanding the evolution of native pinewoods in Scotland will benefit their future management and conservation [PDF]

, 2010
Scots pine (Pinus sylvestris L.) is a foundation species in Scottish highland forests and a national icon. Due to heavy exploitation, the current native pinewood coverage represents a small fraction of the postglacial maximum.
Barton, Davis, FORREST, FORREST, G. R. Iason, Gonzalez-Martinez, J. E. Cottrell, Johnsen, M. J. Salmela, Magri, Naydenov, Neale, PERKS, Provan, R. A. Ennos, Robledo-Arnuncio, Robledo-Arnuncio, S. Cavers, Slatkin, Soranzo, Sork, W. Wachowiak, Yeaman   +22 more
core   +1 more source

Integrated logistic ridge regression and random forest for phenotype-genotype association analysis in categorical genomic data containing non-ignorable missing values

, 2023
Siru Wang, Guoqi Qian, John L. Hopper
openalex   +1 more source

On the Inclusion of Adaptive Potential in Species Distribution Models: Towards a Genomic-Informed Approach to Forest Management and Conservation [PDF]

, 2022
Elia Vajana, Michèle Bozzano, Maurizio Marchi, Andrea Piotti   +3 more
openalex   +1 more source

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

Advanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu, Wenna Duan, Weiwei Tang, Yucheng Zhao, Bin Li   +4 more
wiley   +1 more source

Simultaneous species detection and discovery with environmental DNA metabarcoding: A freshwater mollusk case study

Ecology and Evolution
Environmental DNA (eDNA) sampling is a powerful tool for rapidly characterizing biodiversity patterns for specious, cryptic taxa with incomplete taxonomies.
Daniel D. Vanderpool, Taylor M. Wilcox, Michael K. Young, Kristine L. Pilgrim, Michael K. Schwartz   +4 more
doaj   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Use of Neurospora crassa as fungus model for systems biology of Moniliophthora perniciosa hyphae proteins: case study of polygalacturonases : S01P13 [PDF]

, 2013
Moniliophthora perniciosa, the fungus responsible for the witches' broom disease, brought serious problems to cacao (Theobroma cacao L.) cultivation in the infected areas such as in Southern Bahia, Brazil.
Carvalho, H.A.S., Micheli, Fabienne, Silva, Edson M.A   +2 more
core  

Habitat fragmentation reshapes genomic footprints of selection in a forest herb [PDF]

, 2023
Frederik Van Daele, Olivier Honnay, Hanne De Kort   +2 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source