Results 111 to 120 of about 120,987 (294)

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms [PDF]

, 2004
We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with
Aerts, Andrea, Andersson, Björn, Andersson, Leif, Bartley, Neil, Boardman, Paul E, Bovenhuis, Henk, Brandström, Mikael, Bumstead, Nat, Burt, David W, Chen, Chen, Chen, Jie, Cheng, Hans H, Consortium, International Chicken Polymorphism Map, Crooijmans, Richard P M A, Dai, Mingtao, de Koning, Dirk-Jan, Dong, Le, Dong, Wei, Ellegren, Hans, Glavina, Tijana, Gordon, Laurie, Groenen, Martien A M, Gunnarsson, Ulrika, Hao, Bailin, He, Dandan, He, Ximiao, Hillier, Ladeana W, Hocking, Paul M, Hu, Songnian, Huang, Xiangang, Huang, Yanqing, Hubbard, Simon J, Hunt, Henry, Kaiser, Pete, Kaufman, Jim, Kindlund, Ellen, Lamont, Susan J, Lan, Fengdi, Law, Andy, Li, Dawei, Li, Guangyuan, Li, Guoqing, Li, Heng, Li, Jun, Li, Ning, Li, Ruiqiang, Li, Shengting, Li, Songgang, Li, Wenjie, Li, Yuanzhe, Lin, Wei, Liu, Bin, Lucas, Susan, Meng, Qingshun, Morrice, David, Ni, Peixiang, Ovcharenko, Ivan, Overton, Ian M, Ponting, Chris, Qi, Qiuhui, Ran, Longhua, Rogers, Sally, Rothwell, Lisa, Ruan, Jue, Shi, Jianping, Stubbs, Lisa, Sun, Yongqiao, Tammi, Martti T, Tang, Haizhou, Tong, Wei, van der Poel, Jan J, van Hateren, Andy, Wahlberg, Per, Walker, Brian A, Wang, Jian, Wang, Jianjun, Wang, Jing, Wang, Jun, Wang, Miaoheng, Wang, Pei, Wang, Xiaoling, Warren, Wesley C, Webber, Caleb, Wei, Dong Qing, Wei, Ning, Wilson, Richard K, Wilson, Stuart A, Wong, Gane Ka-Shu, Xi, Yan, Xie, Fei, Yang, Huanming, Yang, Ning, Yang, Shiaw-Pyng, Yang, Xu, Yang, Zheng, Ye, Chen, Ye, Jia, Young, John R, Yu, Jun, Yu, Yingpu, Zeng, Changqing, Zhang, Jianguo, Zhang, Jingjing, Zhang, Xiaowei, Zhang, Yunze, Zhang, Zengjin, Zhang, Zhenpeng, Zhang, Zhi-Yong, Zhao, Wenming, Zhao, Yiqiang, Zheng, Hongkun, Zheng, Weimou, Zhou, Huaijun, Zhou, Jun, Zhou, Yan   +114 more
core   +3 more sources

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Machine Learning and Integrative Analysis of Biomedical Big Data. [PDF]

, 2019
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome)
Choi, Howard, Chung, Neo Christopher, Mirza, Bilal, Ping, Peipei, Wang, Jie, Wang, Wei   +5 more
core   +1 more source

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

Simultaneous species detection and discovery with environmental DNA metabarcoding: A freshwater mollusk case study

Ecology and Evolution
Environmental DNA (eDNA) sampling is a powerful tool for rapidly characterizing biodiversity patterns for specious, cryptic taxa with incomplete taxonomies.
Daniel D. Vanderpool, Taylor M. Wilcox, Michael K. Young, Kristine L. Pilgrim, Michael K. Schwartz   +4 more
doaj   +1 more source

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

16S rRNA sequencing reveals likely beneficial core microbes within faecal samples of the EU protected slug Geomalacus maculosus [PDF]

, 2018
The EU-protected slug Geomalacus maculosus Allman occurs only in the West of Ireland and in northern Spain and Portugal. We explored the microbial community found within the faeces of Irish specimens with a view to determining whether a core microbiome ...
Gormally, Mike, Ijaz, Umer Zeeshan, Reich, Inga, Smith, Cindy J.   +3 more
core   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source