Results 51 to 60 of about 1,197,962 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

High risk, high gain? Trade-offs between growth and resistance to extreme events differ in northern red oak (Quercus rubra L.)

Frontiers in Plant Science
Information about the resistance and adaptive potential of tree species and provenances is needed to select suitable planting material in times of rapidly changing climate conditions.
Jonathan M. Kormann, Jonathan M. Kormann, Ernst van der Maaten, Mirko Liesebach, Katharina J. Liepe, Katharina J. Liepe, Marieke van der Maaten-Theunissen   +6 more
doaj   +1 more source

Environmental change impacts on the C- and N-cycle of European forests: a model comparison study [Discussion paper] [PDF]

, 2012
Forests are important components of the greenhouse gas balance of Europe. There is considerable uncertainty about how predicted changes to climate and nitrogen deposition will perturb the carbon and nitrogen cycles of European forests and thereby alter ...
Butterbach-Bahl, Klaus, Cameron, David R., De Vries, Wim, Grote, Rüdiger, Haas, Edwin, Heuvelink, Gerardus Bernardus Maria, Kiese, Ralf, Kros, Johannes, Kuhnert, Matthias, Leip, Adrian, Oijen, Marcel van, Reinds, Gert Jan, Reuter, Hannes Isaak, Schelhaas, Mart Jan, Werner, Christian, Yeluripati, Jagadeesh   +15 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Influence of crown morphology and branch architecture on tree radial growth of drought-affected Fagus sylvatica L.

Forest Ecosystems
Trees are able to adapt to changing environmental conditions through modifications in their crown morphology and branch architecture. In light-limited environments, tree structures are mainly optimised to increase light interception. This might have side
Katja Kröner, Elena Larysch, Zoe Schindler, Nora Obladen, Julian Frey, Dominik Florian Stangler, Thomas Seifert   +6 more
doaj   +1 more source

Wood density variations of Norway spruce (Picea abies (L.) Karst.) under contrasting climate conditions in southwestern Germany

Annals of Forest Research, 2013
We analyzed inter-annual variations in ring width and maximum wood density of Norway spruce (Picea abies (L.) Karst.) at different altitudes in Baden-Württemberg, southwestern Germany, to determine the climate response of these parameters under ...
Marieke van der Maaten-Theunissen, Simon Boden, Ernst van der Maaten   +2 more
doaj   +1 more source

Prediction of tree crown width in natural mixed forests using deep learning algorithm

Forest Ecosystems, 2023
Crown width (CW) is one of the most important tree metrics, but obtaining CW data is laborious and time-consuming, particularly in natural forests. The Deep Learning (DL) algorithm has been proposed as an alternative to traditional regression, but its ...
Yangping Qin, Biyun Wu, Xiangdong Lei, Linyan Feng   +3 more
doaj   +1 more source

Tropical forest restoration: Fast resilience of plant biomass contrasts with slow recovery of stable soil C stocks [PDF]

, 2017
Due to intensifying human disturbance, over half of the world's tropical forests are reforested or afforested secondary forests or plantations. Understanding the resilience of carbon (C) stocks in these forests, and estimating the extent to which they ...
Ciais P., FAO, Gu W., IPCC, Li Q., Li Z., Liu G., Lyu M., R Core Team, Wang F., Wen D., Yao Q., Yu Z.   +12 more
core   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Optimizing line-plot size for personal laser scanning: modeling distance-dependent tree detection probability along transects

iForest - Biogeosciences and Forestry
Personal laser scanning (PLS) systems are gaining popularity in forest inventory research and practice. They are primarily utilized on circular or compact rectangular sample plots to mitigate potential instrument drift and enhance tree detection rates ...
Ritter T, Tockner A, Krassnitzer R, Witzmann S, Gollob C, Nothdurft A   +5 more
doaj   +1 more source