Results 141 to 150 of about 282,730 (258)
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester +6 morewiley +1 more sourceRegion-specific forest structure pathways reveal climate effects on old-growth tropical forest biomass. [PDF]
Sci RepDepoortere P, Bauman D, Fayolle A, Phillips O, Bialic-Murphy L, Zohner CM, Vander Linden A, Plumacker A, de Lame H, Liang J, Reich PB, Gamarra JGP, Alberti G, Hérault B, Picard N, de-Miguel S, Nabuurs GJ, Crowther TW, Paquette A, Pretzsch H, Wiser SK, Zhou M, Chen HYH, Verbeeck H, De Cannière C, Sullivan MJP, Poorter L, Ponette Q, Bauters M, Deblauwe V, Keppel G, Brearley FQ, Zo-Bi IC, Ouattara TA, Lawes MJ, Bongers F, Meave JA, Schulze M, Ngoh ML, Ter Steege H, Homeier J, Azihou AF, Trethowan L, Slik JWF, Derroire G, Bonal D, Laurance WF, Hemp A, Murdjoko A, Aguirre-Gutiérrez J, Kintamani E, White L, Lewis SL, Hector A, Amani C, Andrade A, Angbonga A, Aragão L, Kurian A, Allah Barem F, Almeyda Zambrano AM, Alvarez-Davila E, Alvarez-Loayza P, Amstrong E, Araujo-Murakami A, Arroyo L, Baker TR, Bako O, Bánki O, Baraloto C, Barbier N, Barroso JG, Bassama P, Beeckman H, Benu NMH, Bihiya H, Birnbaum P, Bitariho R, Boeckx P, Boekee K, Bogaert J, Böhning-Gease K, Boyemba F, Brandão da Cunha H, Brienen R, Briseño-Reyes J, Broadbent EN, Camargo JL, Cassart B, Cazzolla Gatti R, Chave J, Chuyong G, Clark DB, Clark C, Collalti A, Collins M, Cornejo Valverde F, Corral-Rivas JJ, Couteron P, Cuni-Sanchez A, da Costa L, Daniel Soto J, Dar AA, Dar JA, Dauby G, de Haulleville T, Di Fiore A, Diisi J, Djuikouo K MN, Dolezal J, Dongmo N, Doucet JL, Droissart V, Engel J, Engone Obiang NL, Espinosa S, Eyre T, Fauset S, Feldpausch TR, Fischer M, Gajapersad K, Girmansyah D, Gloor E, Gomes do Amaral I, Gonmadje CF, Grieco E, Grogan J, Habonayo R, Harris DJ, Honorio Coronado E, Huamantupa-Chuquimaco I, Hubau W, Jansen PA, Jeffery KJ, Jumbam B, Kanda NB, Kamdem N, Kasongo Yakusu E, Katembo J, Kayijamahe C, Kearsley E, Kenfack D, Khan ML, Killeen T, Kothandaraman S, Kougue R, Kumar A, Kuswandi R, Labrière N, Lasso D, Laurance S, Leal M, Leblanc H, Libalah M, Lisingo J, Malhi Y, Marimon BS, Marimon Junior BH, Marshall AR, Martin EH, Martin-Ducup O, Mbasi MM, Mbayu F, Mendoza C, Mendoza Polo I, Mofack G, Monteagudo-Mendoza A, Mtui A, Muthuramkumar S, Narayanan A, Nava-Miranda MG, Neill D, Neldner VJ, Tchatchouang EN, Ngoula F, Ngugi MR, Sainge MN, Núñez Vargas P, Ortiz-Malavassi E, Pallqui Camacho N, Pandi V, Parada Gutierrez GA, Pardo G, Parthasarathy N, Pelissier R, Pfautsch S, Pijanowski BC, Piotto D, Pipoly J, Pitman N, Ploton P, Poulsen JR, Ramesh BR, Ramirez Arevalo F, Ramírez-Angulo H, Rasingam L, Réjou-Méchain M, Restrepo Correa Z, Spironello WR, Rodrigues de Souza C, Rodriguez LO, Rolim S, Roopsind A, Rovero F, Sagang LB, Saikia P, Salis A, Salla BP, Silva Espejo JE, Silveira M, Simo-Droissart M, Sirri N, Sonké B, Sundarapandian S, Swaine M, Swanepoel B, Taedoumg H, Tcheferi I, Terborgh J, Thomas D, Thomas R, Tshibamba Mukendi J, Umunay PM, Valencia R, Valenzuela Gamarra L, Valle Ferreira L, van der Heijden G, Vasquez Martinez R, Vega-Nieva JD, Vilanova E, Vilchez Alvarado B, Vinceti B, Vleminckx J, von Gadow K, Vos VA, Wasingya E, Watson J, Wortel V, Zagt R, Zébazé D, ForestPlots.net, GFBI, Bastin JF. +242 moreeuropepmc +1 more sourceNanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy
Advanced Science, EarlyView.TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT
Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao +9 morewiley +1 more sourceAssociations of Happiness, <i>Ikigai</i>, and Enjoyment of Daily Life with Frequency of Forest Walking in a Japanese General Population: The Japan Multi-Institutional Collaborative Cohort Daiko Study. [PDF]
Int J Environ Res Public HealthMorita E, Kawai S, Sasakabe T, Okada R, Kubo Y, Mitsuda Y, Kato Y, Matsunaga T, Nagayoshi M, Tamura T, Wakai K. +10 moreeuropepmc +1 more sourceTSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response
Advanced Science, EarlyView.TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li +8 morewiley +1 more sourceArchitecture‐Engineered Semi‐Crystalline Microporous Polymer Membranes for Precise Molecular Separation
Advanced Science, EarlyView.Guided by a Random Forest model, a π–π‐driven ordered stacking strategy deploys functionally distinct substructures to restrict chain segment motion and increase free volume, while preserving the intermolecular interactions that maintain structural integrity.Zi‐Meng Xu, Hao Zhuo, Song‐Hui Zhi, Xiao‐Feng Zhong, Pan‐Pan Zhang, Si‐Yuan Yang, Wen‐Yong Yang, Guang‐Yong Shen, Ya‐Zhao Li, Yi Li, Ming Xue +10 morewiley +1 more sourceMulti‐Scale Bionic Structure Constructs Biomass Flame‐Retardant Thermal Insulation Foam Material
Advanced Science, EarlyView.Inspired by mussel adhesion and hierarchical brick‐and‐mortar architectures, a cellulose‐based biomimetic foam is constructed by anchoring bentonite nanosheets onto a polydopamine‐decorated cellulose nanofiber network. The resulting foam combines low thermal conductivity with intrinsic flame retardancy and full biodegradability, presenting a ...Jianming Liao, Lijun Fan, Yunyuan Dong, Xuyu Bao, Xiaobin Chen, Qifu Zheng, Guanqing Zhang, Shen Wang, Wei Chen, Min Zhang, Shuaiming He +10 morewiley +1 more source