Results 161 to 170 of about 33,015,016 (348)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Elucidating HER2-directed chimeric antigen receptor (CAR) activation mechanism using homology modeling and all-atom molecular dynamics simulation. [PDF]

Comput Struct Biotechnol J
Hryb M, Davis L, Lao S, Paradis NJ, Staehle M, Mou X, Wu C.   +6 more
europepmc   +1 more source

Efficiently computing static single assignment form and the control dependence graph

ACM Transactions on Programming Languages and Systems, 1991
R. Cytron, J. Ferrante, B. Rosen, M. Wegman, F. K. Zadeck   +4 more
semanticscholar   +1 more source

Surgery obstructions on closed manifolds and the inertia subgroup

, 2012
Hambleton, I.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The 3d Mixed BF Lagrangian 1-Form: A Variational Formulation of Hitchin's Integrable System. [PDF]

Commun Math Phys
Caudrelier V, Harland D, Singh AA, Vicedo B.   +3 more
europepmc   +1 more source

A Closed-Form Solution to Natural Image Matting

IEEE Transactions on Pattern Analysis and Machine Intelligence, 2006
Anat Levin, Dani Lischinski, Yair Weiss
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Impact of an assessment form on promoting in-hospital initiation of sodium-glucose cotransporter-2 inhibitors in hospitalized patients with heart failure. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Okamoto T, Matsumura K, Miyata H, Kimoto Y, Hamamura K, Kato K, Hakozaki S, Yagi E, Ueno M, Fujiwara K, Takegami M, Nakazawa G.   +11 more
europepmc   +1 more source