Results 171 to 180 of about 1,995,130 (199)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

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A numerical study on establishing the forming limit curve and indicating the formability of complex shape in incremental sheet forming process

International Journal of Precision Engineering and Manufacturing, 2013
In order to obtain a final sound product by the incremental sheet forming (ISF) process for complex shape using cold rolled steel material, the limit curve based on the maximum wall angle versus maximum deformed height was established utilizing finite element method (FEM) simulations for several square shapes with various wall angles. The forming limit
Young-Suk KIM, Duc-Toan Nguyen
exaly   +2 more sources

Formability Analysis of Fukui Stretch-Drawing and Square Cup Drawing Using Strain and Stress Based Forming Limit Curves

Key Engineering Materials, 2017
In this work, the experimental and numerical analyses of Forming Limit Curve (FLC) and Forming Limit Stress Curve (FLSC) for Advanced High Strength Steel (AHSS) sheet, grade JAC780Y, are performed. Initially, the FLC is experimentally determined by means of the Nakazima Stretch forming test.
Sansot Panich, Nopparat Seemuang, Taratip Chaimongkon   +2 more
openaire   +2 more sources

Formability prediction of high‐strength steel sheet using experimental, analytical and theoretical analysis based on strain and stress forming limit curves and its application to automotive forming parts

Materialwissenschaft und Werkstofftechnik, 2023
AbstractIn this work, the high‐strength steel (HSS) sheet dual‐phase 440 (DP440) were conducted to establish the forming limit curve (FLC) and analytical forming limit stress curve (FLSC) obtained from experimental forming limit curve. First, the Nakajima stretch forming examination was carried out to obtain forming limit curve of investigated sheet ...
A. Nakwattanaset, S. Panich, S. Suranuntchai   +2 more
openaire   +1 more source

Influence of the strain path changes on the formability of a zinc sheet

Journal of Materials Processing Technology, 2019
International audienceThe formability of sheet metals is frequently characterized by the forming limit curve (FLC), which is determined by applying proportional loading paths until the onset of necking.
Javier Signorelli, Nathalie Bozzolo
exaly   +2 more sources

Orientation and Path Dependence of Formability in the Stress- and the Extended Stress-Based Forming Limit Curves

Journal of Engineering Materials and Technology, 2008
This article analyzes the formability data sets for aluminum killed steel (Laukonis, J. V., and Ghosh, A. K., 1978, “Effects of Strain Path Changes on the Formability of Sheet Metals,” Metall. Trans. A., 9, pp. 1849–1856), for Al 2008-T4 (Graf, A., and Hosford, W., 1993, “Effect of Changing Strain Paths on Forming Limit Diagrams of Al 2008-T4,” Metall.
C. Hari Manoj Simha, Kaan Inal, Michael J. Worswick   +2 more
openaire   +1 more source

Formability Limiting Curve of Mild Steel by Explosive Forming

1990
At the advent of increasing interest in high velocity forming techniques, the knowledge of maximum extent of formation without the risk of any failure becomes necessary. A Formability Limit Curve will represent a critical level curve separating FAIL region from SAFE region.
K. Raghukandan, P. V. Vaidyanathan, M. Rathinasabapathi   +2 more
openaire   +1 more source

Study on the Formability and its Geometric Factors of Seamed Tube Hydroforming

Advanced Materials Research, 2011
Forming limit curve (FLC) is an important tool for assessing formability of steel metal. It is commonly obtained from experiment, theoretical calculation and finite element method (FEM) simulation.
Shu Hui Li
exaly   +2 more sources