Results 81 to 90 of about 1,076 (248)

The effect of strain rate on position of forming limit curve

, 2020
Diplomová práce se zabývá vlivem rychlosti deformace na zásobu plasticity materiálů. Teoretická část pojednává o tváření se zaměřením na hodnocení tvářitelnosti pomocí FLD diagramů, které jsou nezbytné pro návrh lisovacích operací, a to zejména v ...
Ondřej Hák
core  

EFFECT OF BENDING ON FORMABILITY LIMITS [PDF]

, 2010
In order to fulfill new environmental regulations to reduce Greenhouse Gas Emissions (GHG), new grades of Advanced High-Strength Steel (AHSS) have been replacing conventional steels in vehicle’s body structures.
Martinez Lopez, A., van den Boogaard, Antonius H.; id_orcid   +1 more
core   +1 more source

An in-plane tensile test for rheological and formability identification : comparison between experimental and numerical FLC

, 2011
International audienceBoth accurate constitutive laws and formability limits of materials are essential for a numerical optimization of sheet forming processes. To identify these behaviors, experimental databases are needed. In this work, experiments are
Ragneau, Eric, Leotoing, Lionel, D. Guines, Guines, Dominique, L. Leotoing, E. Ragneau   +5 more
core   +2 more sources

Research on Alloy Design and Process Optimization of Al–Mg–Zn-Cu-Based Aluminum Alloy Sheets for Automobiles with Secured Formability and Bake-Hardenability

Metals
In this study, the compositional design of high-formability, high-bake-hardening Al–Mg–Zn-Cu-based aluminum alloys was carried out, and process conditions were established to secure mechanical properties under harsh conditions for Al–Mg–Zn-Cu-based ...
GyeongSeok Joo, SeungGyu Choi, YoungKil Jung, SeHoon Kim, JaeHyuck Shin   +4 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A statistical method for determining and representing formability : innovation report [PDF]

Formability, conventionally characterised by the Forming Limit Curve (FLC), is a critical measure used to define the working limit of sheet metal in a forming operation. The FLC defines the limit strain the material can undergo before failure occurs. The
Small, Neil
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Artificial neural network-based prediction of complete forming limit curves for steel in sheet metal forming

Journal of Alloys and Metallurgical Systems
Forming Limit Curve (FLC) is crucial for predicting material formability and preventing defects in the sheet metal forming industry. Traditionally, FLCs are determined through Nakajima and Marciniak tests, which assess the material's response to various ...
Shivesh Kumar Sharan, Surajit Kumar Paul, Jyoti Kumari, Arijit Mondal   +3 more
doaj   +1 more source