Results 51 to 60 of about 368,952 (258)

Formal Context Transforms and Their Affordances for Exploratory Data Analysis

Mathematics
Consider a formal context (G, M, I) as the basic mechanism to capture information about a set G of objects, a set M of attributes and the relation I ∈ G × M between them. Traditional use of Formal Concept Analysis has some shortcomings in its information-
Francisco J. Valverde-Albacete, Carmen Peláez-Moreno, Inma P. Cabrera, Pablo Cordero, Manuel Ojeda-Aciego   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

On the Computation of Concept Stability Based on Maximal Non-Generator for Social Networking Services

Applied Sciences, 2020
The concept stability measure under the Formal Concept Analysis (FCA) theory is useful for improving the accuracy of structure identification of social networks.
Jie Gao, Fei Hao, Doo-Soon Park
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A formal instructional model based on Concept Maps

Je-LKS: Journal of E-Learning and Knowledge Society, 2009
The aim of this paper is to show a new model (under development by the E-Learning & Knowledge Management Laboratory at the University of Genoa) for designing and developing units of learning.
Giovanni Adorni, Diego Brondo, Giuliano Vivanet   +2 more
doaj   +1 more source

Relationship Between Attribute (Object) Oriented Multi-Granularity Concept Lattices

Jisuanji kexue yu tansuo, 2020
According to the inspiration of research on multi-granularity marker information system in rough set, for the formal background of multi-granularity marker, concept lattices made by different granularity markers have connections.
YANG Han, QIN Keyun
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Formalizing ICD coding rules using Formal Concept Analysis

Journal of Biomedical Informatics, 2009
With the 11th revision of the International Classification of Disease (ICD) being officially launched by the World Health Organization (WHO), the significance of a formal representation for ICD coding rules has emerged as a pragmatic concern.To explore the role of Formal Concept Analysis (FCA) on examining ICD10 coding rules and to develop FCA-based ...
Jiang, Guoqian, Pathak, Jyotishman, Chute, Christopher G.   +2 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source