Results 71 to 80 of about 449,079 (306)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Learning Services Based on Formal Concept Reasoning [PDF]
, 2007 A formal foundation of automated service discovering for Semantic Web is proposed. The approach is based on the formalization of the problem using an agent oriented programming language (ConGolog), as well as on the use of the Formal Concept Analysis ...
Borrego Díaz, Joaquín +2 more
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Formal Context Transforms and Their Affordances for Exploratory Data Analysis
MathematicsConsider a formal context (G, M, I) as the basic mechanism to capture information about a set G of objects, a set M of attributes and the relation I ∈ G × M between them. Traditional use of Formal Concept Analysis has some shortcomings in its information-
Francisco J. Valverde-Albacete +4 more
doaj +1 more source
Applied Sciences, 2020 The concept stability measure under the Formal Concept Analysis (FCA) theory is useful for improving the accuracy of structure identification of social networks.
Jie Gao, Fei Hao, Doo-Soon Park
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
An application of formal concept analysis to neural decoding
, 2012 This paper proposes a novel application of Formal Concept Analysis (FCA) to neural decoding: the semantic relationships between the neural representations of large sets of stimuli are explored using concept lattices.
Priss, U, Endres, D M, Foldiak, Peter
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A formal instructional model based on Concept Maps
Je-LKS: Journal of E-Learning and Knowledge Society, 2009 The aim of this paper is to show a new model (under development by the E-Learning & Knowledge Management Laboratory at the University of Genoa) for designing and developing units of learning.
Giovanni Adorni +2 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source