Results 61 to 70 of about 934,075 (313)

Definitions of the Terms Open, Distance, and Flexible in the Context of Formal and Non-Formal Learning

Journal of Open, Flexible and Distance Learning, 2023
This opinion piece seeks to define and contextualise educational terms that are used, and appear to be misused, in contemporary academic literature and practice.
Simon Paul Atkinson
doaj   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Formal Contexts for Algebraic Domains

Electronic Notes in Theoretical Computer Science, 2014
AbstractIn this paper, we investigate the representation of algebraic domains by means of Formal Concept Analysis. For a formal context, we can define a large number of consistent sets. Associated with each consistent set, there is a set of F-approximable concepts which are selected from the well known approximable concepts. By virtue of F-approximable
Mengqiao Huang, Qingguo Li, Lankun Guo
openaire   +1 more source

Modeling Adaptation with Klaim [PDF]

, 2012
In recent years, it has been argued that systems and applications, in order to deal with their increasing complexity, should be able to adapt their behavior according to new requirements or environment conditions.
R. Pugliese, Pugliese, Rosario, E. Gjondrekaj, Gjondrekaj, Edmond, Loreti, Michele, Tiezzi, Francesco, M. Loreti   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

EDUCAŢIA DE GEN ÎN CONTEXT FORMAL-NONFORMAL-INFORMAL

Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2020
În prezentul articol este abordată educația de gen. Constatările și concluziile sunt făcute în baza analizei unor experiențe practice, subiectul fiind explorat în context formal-nonformal-informal.
USM ADMIN
doaj  

Safe abstractions of data encodings in formal security protocol models [PDF]

, 2014
When using formal methods, security protocols are usually modeled at a high level of abstraction. In particular, data encoding and decoding transformations are often abstracted away.
Pironti, Alfredo, Sisto, Riccardo
core   +1 more source