Results 81 to 90 of about 849,683 (262)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Formal Modeling and Verification of Context-Aware Systems using Event-B
EAI Endorsed Transactions on Context-aware Systems and Applications, 2014 Context awareness is a computing paradigm that makes applications responsive and adaptive with their environment. Formal modeling and verification of context-aware systems are challenging issues in the development as they are complex and uncertain.
Hong Anh Le, Ninh Thuan Truong
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
(In)formal Requests in Students’ Emails in an Academic Context
ELOPEThis paper aims to provide an overview of the rhetorical strategies found in university students’ emails when they write to faculty members. The analysis is based on a self-compiled corpus of 100 emails written in English and sent to the author by the ...
Vesna Lazović
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Forgetting-Based Concept-Cognitive Learning for Classification in Fuzzy Formal Decision Context
AxiomsConcept-cognitive learning reveals the principle of human cognition by simulating the brain’s process of learning and processing concepts. Nevertheless, for neighborhood similarity granules, the average information of objects regarding all attributes is ...
Chuanhong Sun +2 more
doaj +1 more source
A Formal Context for Acyclic Join Dependencies [PDF]
, 2017 Acyclic Join Dependencies (AJD) play a crucial role in database design and normalization. In this paper, we use Formal Concept Analysis (FCA) to characterize a set of AJDs that hold in a given dataset. This present work simplifies and generalizes the characterization of Multivalued Dependencies with FCA.
openaire +3 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source