Results 51 to 60 of about 2,757,674 (305)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Attributes Of Police Leadership
Revista Criminalidad, 2019 The purpose of this article is to identify the attributes of police leadership and their relationships, associated with the dimensions of to be, to know, know-how, and know to be of the police officer. The methodological design used is of mixed type. For
Juan Carlos Nieto-Aldana +2 more
doaj
Via Inveniendi Et Iudicandi, 2022 La impunidad puede ser leída como una categoría formal (objetiva) o informal (subjetiva); en Colombia, predomina su concepción en la dimensión subjetiva.
Germán Silva García
doaj +1 more source
Post-Socialist Anomie Through the Lens of Economic Modernization and the Formalization of Social Control [PDF]
SSRN Electronic Journal, 2013 This paper inquires into how economic modernization impacts normative regulation by spurring, on the one hand (a) formal media of normative regulation (also known as formal social control) in the spheres of politics, economics and interpersonal relations and, on the other hand, (b) informality via the lower density of norms (also known as anomie). This
Christopher Swader, Leon Kosals
openaire +1 more source
Informal Authority in the Workplace [PDF]
, 2010 {Excerpt} In most types of organizations, formal authority is located at the top as part of an exchange against fairly explicit expectations. In networked, pluralistic organizations that must rapidly formulate adaptive solutions in an increasingly ...
Serrat, Olivier
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Sociological concept of morale [PDF]
Zbornik Radova: Pravni Fakultet u Novom Sadu, 2012 The author first discusses the overall unity of the total normative regulation, from which it is separated in the late Roman empire the right, but only in the new century and the morale.
Marjanović Miloš
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source