Results 71 to 80 of about 591,091 (290)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
On formal verification of arithmetic-based cryptographic primitives
, 2009 Cryptographic primitives are fundamental for information security: they are used as basic components for cryptographic protocols or public-key cryptosystems.
A.C. Yao +11 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Formal Verification of Differential Privacy for Interactive Systems
, 2011 Differential privacy is a promising approach to privacy preserving data analysis with a well-developed theory for functions. Despite recent work on implementing systems that aim to provide differential privacy, the problem of formally verifying that ...
Datta, Anupam +2 more
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Towards Formal Verification of ToolBus Scripts [PDF]
, 2008 ToolBus allows one to connect tools via a software bus. Programming is done using the scripting language Tscript, which is based on the process algebra ACP. Tscript was originally designed to enable formal verification, but this option has so far not been explored in any detail.
Fokkink, W. +3 more
openaire +5 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Towards a methodology for rigorous development of generic requirements patterns
, 2005 We present work in progress on a methodology for the engineering, validation and verification of generic requirements using domain engineering and formal methods.
Johnson, Ian +2 more
core
Formal verification of an autonomous personal robotic assistant [PDF]
, 2014 Human–robot teams are likely to be used in a variety of situations wherever humans require the assistance of robotic systems. Obvious examples include healthcare and manufacturing, in which people need the assistance of machines to perform key tasks.
Dautenhahn, K. +6 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source