Results 31 to 40 of about 530,095 (206)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Quasi-Periodic Formaldehyde Maser Flares in the Massive Protostellar Object IRAS18566+0408

, 2010
We report results of an extensive observational campaign of the 6 cm formaldehyde maser in the young massive stellar object IRAS18566+0408 (G37.55+0.20) conducted from 2002 to 2009.
Araya, Araya, Araya, Araya, Araya, Araya, Araya, Artymowicz, Eyer, Garay, Hoffman, Jensen, Mundt, Sridharan   +13 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Morphometric alterations to the rat spleen following formaldehyde exposure [PDF]

, 2008
Formaldehyde is commonly used in the production of various industrial and medical products. At room temperature formaldehyde easily evaporates. Exposure to formaldehyde can be hazardous to human health.
Azarhoush, R., Davarian, A., Fazeli, S.A., Ghafari, S., Gharravi, A.M., Golalipour, M.J., Kord, H.   +6 more
core  

Electron-impact spectroscopy of acetaldehyde [PDF]

, 1987
Acetaldehyde has been studied by the technique of low‐energy variable‐angle electron energy‐loss spectroscopy. With this method the low‐lying spin‐forbidden transitions have been located via the behavior of the relative differential cross sections ...
Koerting, C. F., Kuppermann, A., Walzl, K. N.   +2 more
core   +1 more source

Vortex fluidics-mediated DNA rescue from formalin-fixed museum specimens. [PDF]

, 2020
DNA from formalin-preserved tissue could unlock a vast repository of genetic information stored in museums worldwide. However, formaldehyde crosslinks proteins and DNA, and prevents ready amplification and DNA sequencing.
Girguis, Peter R, Majumdar, Sudipta, Phillips, Jessica M, Raston, Colin L, Reese, Aspen T, Totoiu, Christian A, Weiss, Gregory A   +6 more
core   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Nuclear spin conversion in formaldehyde [PDF]

, 2000
Theoretical model of the nuclear spin conversion in formaldehyde (H2CO) has been developed. The conversion is governed by the intramolecular spin-rotation mixing of molecular ortho and para states.
Bahloul, Bauder, Bocquet, Carter, Chapovsky, Chapovsky, Chapovsky, Chapovsky, Chapovsky, Curl, Duxbury, Farkas, Gunther-Mohr, Gus'kov, Gus'kov, Ilisca, Landau, Muller, Nagels, P.L. Chapovsky, Peters, Townes, Watson, Wigner   +23 more
core   +2 more sources