Results 111 to 120 of about 15,779,296 (295)

Efeitos da amitriptilina sobre a modulação da dor aguda, em ratos submetidos à ligadura do nervo ciático

Revista Dor
JUSTIFICATIVA E OBJETIVOS: Diversos sistemas de receptores estão envolvidos na modulação central da dor: noradrenérgico, serotoninérgico e opioide, entre outros.
Naira Correia Cusma Pelógia, Bruna Gouvea Machado, Francielly Capelete Briet de Almeida, Elton Constantino, Oscar César Pires   +4 more
doaj   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Effect of Aqueous Extract of Trigonella foenum-graecum on Pain and Inflammation Induced by Formalin in Male Mice

Journal of Medicinal Plants, 2011
Background: Studies have emphasized the effect of Trigonella foenum-graecum extract on the reduction of pain and inflammation. Objective: In this research we investigated the mechanisms of Trigonella foenum-graecum extract in reducing pain and ...
B Rastegar Moghadam, H Ali-Beig, S Arbabian, Sh Farahbakhsh, F Emami, L Golmanesh, H Zardooz, C Jalili, H Sahraei   +8 more
doaj  

Investigation of noradrenergic receptor system in anti-nociception using formalin test in the naked mole rat (Heterocephalus glaber). [PDF]

Heliyon, 2020
Mwobobia RM, Kanui TI, Abelson KSP.
europepmc   +1 more source

Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test.

Life Science, 2015
A. Holanda, Laila Asth, A. Santos, R. Guerrini, Vanessa de P Soares-Rachetti, G. Calo’, E. André, E. Gavioli   +7 more
semanticscholar   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Antinociceptive Effects of Artemisia persica Boiss Essential Oil in Male Mice Using Formalin and Tail Immersion Tests

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Artemisia species have long been used to relieve neurological and visceral pains. A. persica Boiss is one of the species in the genus Artemisia, which has antioxidant, antimicrobial, and cytotoxic effects. The aim of this study
Tayebeh Ebrahimi, Mahbubeh Setorki, Nasrollah Dastanpour   +2 more
doaj  

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity. [PDF]

Int J Mol Sci, 2020
Szandruk-Bender M, Wiatrak B, Szczukowski Ł, Świątek P, Rutkowska M, Dzimira S, Merwid-Ląd A, Danielewski M, Szeląg A.   +8 more
europepmc   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source