Results 101 to 110 of about 502,783 (343)

Permanent lesion in rostral ventromedial medulla potentiates swim stress-induced analgesia in formalin test [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2014
Objective(s): There are many reports about the role of rostral ventromedial medulla (RVM) in modulating stress-induced analgesia (SIA). In the previous study we demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced ...
Ali Shamsizadeh   +3 more
doaj  

Antinociceptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice

open access: yesThe Pan African Medical Journal, 2013
INTRODUCTION: Toddalia asiatica is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions. The present study investigated the antinociceptive and the anti-inflammatory effects of T.
Hellen Nyambura Kariuki   +4 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Preemptive analgesic effects of midazolam and diclofenac in rat model

open access: yesBiomolecules & Biomedicine, 2011
The aim of the present study was to investigate the preemptive analgesic effects of intraperitoneally administrated midazolam and diclofenac, before acute and inflammatory induced pain in rat model.
Antigona Hasani   +3 more
doaj   +1 more source

Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

open access: yesMolecules, 2020
Aristolochia odoratissima L. is employed for the treatment of pain and as an antidote against the poison of venomous animals in traditional medicine.
Rosa Mariana Montiel-Ruiz   +7 more
doaj   +1 more source

The antinociceptive effect of hydro-alcoholic extract of leave Mentha pulegium in formalin test in male rat [PDF]

open access: yes, 2009
Background and aim: Drug researchers believe that pain relief medicines, because of their side effects and in some cases because of their inabilities are not useful. Therefore, it is necessary to do more research to find out new antinociceptive drugs. In
Khodaparast, Ladan.   +2 more
core  

The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]

open access: yes, 1964
1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

The Effects of Aqueous and Hydroalcoholic Extract of Eugenia Caryophyllata on Formalin Induced Pain in Male Rats

open access: yesJournal of Medicinal Plants, 2012
Background : Pain is an unpleasant sensation experience that motivates when tissues are damaged or threatened. Therefore, humans have always tried to discover how to struggle against it. Nowadays people willing to use plant drugs more than chemical drugs,
M Abbasnejad   +3 more
doaj  

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