Results 111 to 120 of about 6,977,566 (297)

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Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Dual-Acting Peripherally Restricted Delta/Kappa Opioid (CAV1001) Produces Antinociception in Animal Models of Sub-Acute and Chronic Pain

Journal of Pain Research, 2020
Craig T Hartrick,1 Dominic Poulin,2 Rebekka Molenaar,3 Allison Hartrick1 1Caventure Drug Discovery, Bloomfield Hills, MI, USA; 2Charles River Laboratories, Montreal, Canada; 3American Preclinical Services, Minneapolis, MN, USACorrespondence: Craig T ...
Hartrick CT, Poulin D, Molenaar R, Hartrick A   +3 more
doaj  

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

Antinociceptive and Anti-inflammatory Effects of Hydroalchoholic Extract of Anethum graveolens L. seed

Journal of Medicinal Plants, 2010
Background: There are many reports about anti-inflammatory effect of Anethum graveolens L.(A.g) in Iranian traditional medicine. In current decade, based on using of neutriceuticales for healing, the use of herbal drugs became very common.
A Valadi, S Nasri, N Abbasi, GR Amin
doaj  

Enhanced In Vivo Antinociceptive Activity and GC–MS Chemical Profiling of In Vitro-Grown Acmella radicans Plants Elicited with Rhizopus microsporus

Molecules
Pain remains a major global health challenge, driving the search for safer analgesics from medicinal plants. Although Acmella radicans is traditionally used for pain relief, the effects of fungal elicitation on its chemical profile and antinociceptive ...
Giovanna Hernández-Aubert, Rosa Mariana Montiel-Ruiz, Israel Hurtado-Díaz, José Antonio Silva-Guzmán, José Guillermo Torres-Rendón, Ricardo Manríquez-González, Francisco Cruz-Sosa, Antonio Bernabé-Antonio   +7 more
doaj   +1 more source

The antinociceptive effects of a dual kappa-delta opioid receptor agonist in the mouse formalin test. [PDF]

Behav Pharmacol, 2020
Ulker E, Toma W, White A, Uprety R, Majumdar S, Damaj MI.   +5 more
europepmc   +1 more source

Test upload

, 2019
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