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Neuronostatin induces hyperalgesia in formalin test in mice
Neuroscience Letters, 2012Neuronostatin, a newly identified peptide encoded by the somatostatin (SST) gene, was proved to produce significant antinociceptive effect in mouse tail immersion test. However, the effect of neuronostatin on tonic pain was still not clear. The aim of this study was to investigate the effect of neuronostatin in the formalin test and its possible ...
Shao-Bin, Yang +5 more
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Sildenafil increases diclofenac antinociception in the formalin test
European Journal of Pharmacology, 2001The antinociceptive activity of an inhibitor of phosphodiesterase 5, alone or combined with diclofenac, was assessed in the formalin test. Local administration of diclofenac produced a significant antinociception in both phases of the formalin test in female Wistar rats. In contrast, 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [3,4-d]
R, Asomoza-Espinosa +5 more
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Naloxone-induced hypoalgesia: Evidence from the formalin test
Pharmacology Biochemistry and Behavior, 1993Two experiments examined the hypoalgesic effects that accrue from pairing exposure to a heat stressor with the opioid antagonist naloxone. Experiment 1 confirmed that rats given separate exposures to a heated floor and to naloxone are hypoalgesic when then tested on that floor.
H, Foo, R F, Westbrook
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Pharmacology, Biochemistry and Behavior, 2013
Orexin-A and orexin-B are two neuropeptides selectively synthesized in the lateral hypothalamus (LH), a region involved in morphine induced analgesia and pain modulation.
H. Azhdari-Zarmehri +3 more
semanticscholar +1 more source
Orexin-A and orexin-B are two neuropeptides selectively synthesized in the lateral hypothalamus (LH), a region involved in morphine induced analgesia and pain modulation.
H. Azhdari-Zarmehri +3 more
semanticscholar +1 more source
Habenular stimulation produces analgesia in the formalin test
Neuroscience Letters, 1986Electrical stimulation of the habenula produces a striking reduction of continuous, formalin-induced pain in the rat. The analgesia occurs at current levels which do not appear aversive and persists for variable durations, ranging from 1 to 21 min in this experimental situation.
S R, Cohen, R, Melzack
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Antinociceptive effect of gabapentin in the formalin test
Methods and Findings in Experimental and Clinical Pharmacology, 1999Gabapentin is an adjunctive drug for the treatment of resistant partial seizures. The antinociceptive effect of this drug was assessed by using the formalin pain test in rats. Although low dose gabapentin (10 mg/kg s.c.) was unable to alter pain scores, higher doses (30 and 90 mg/kg s.c.) significantly reduced them.
R, Dixit, V K, Bhargava, N, Kaur
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Imipramine-Induced Antinociception in the Formalin Test
Pharmacology, 2003This study concerned the effect of swim stress on imipramine-induced antinociception in mice. The data showed that intraperitoneal (i.p.) administration of different doses of imipramine (10–40 mg/kg) and 0.5–3 min of swim stress (17°C) induced antinociception in the first and second phases of the formalin test. Low period of swim stress (10 s) with low
Mohammad-Reza Zarrindast +2 more
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d-Methadone Is Antinociceptive in the Rat Formalin Test
The Journal of Pharmacology and Experimental Therapeutics, 1997The l-isomer of methadone possesses opioid activity, whereas the d-isomer is weak or inactive as an opioid. Both d- and l-methadone have been shown to bind to the N-methyl-D-aspartate (NMDA) receptor. To determine whether d-methadone has functional, in vivo NMDA receptor antagonist activity, the antinociceptive effects of d-methadone were evaluated in ...
N, Shimoyama +3 more
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Journal of Pharmacology and Experimental Therapeutics, 1992
Subcutaneous injection of formalin into the dorsal surface of the hindpaw evoked a two-phased flinching (phase 1:0-9 min; phase 2: 10-60 min) of the injected paw.
A. Malmberg, T. Yaksh
semanticscholar +1 more source
Subcutaneous injection of formalin into the dorsal surface of the hindpaw evoked a two-phased flinching (phase 1:0-9 min; phase 2: 10-60 min) of the injected paw.
A. Malmberg, T. Yaksh
semanticscholar +1 more source
The rat paw formalin test: comparison of noxious agents
Pain, 1990A comparison was made of the spontaneous nociceptive behaviors elicited by s.c. injection into the rat hind paw of the following 8 irritants: acetic acid, carrageenan, formalin, kaolin, platelet-activating factor, mustard oil (given topically), serotonin, and yeast.
Helen, Wheeler-Aceto +2 more
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