Results 241 to 250 of about 6,977,566 (297)

The formalin test: Effects of formalin concentration and short-term halothane inhalation

Regional Anesthesia and Pain Medicine, 2001
In order to evaluate the effects of formalin concentration and inhalational anesthetics in formalin tests, we injected 5 concentrations of formalin into awake and anesthetized rats and investigated their behavior and the c-fos immunoreactivity of their spinal cords.Sixty adult male Sprague-Dawley rats were divided into 10 experimental groups.
T, Fukuda, C, Nishimoto, Y, Shiga, H, Toyooka   +3 more
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Improving the efficiency of the formalin test

Pain, 1999
A time-sampling method that allows up to eight rats to be tested simultaneously in the formalin test is described and compared to the continuous rating method. Time sampling the behavioural response to formalin every 1 or 2 min produces scores that are essentially identical to continuous rating for both the formalin concentration effect relationship ...
Frances V, Abbott, Rok, Ocvirk, Robert, Najafee, Keith B J, Franklin   +3 more
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The formalin test: an evaluation of the method

Pain, 1992
The formalin test for nociception, which is predominantly used with rats and mice, involves moderate, continuous pain generated by injured tissue. In this way it differs from most traditional tests of nociception which rely upon brief stimuli of threshold intensity.
Arne, Tjølsen, Odd-Geir, Berge, Steinar, Hunskaar, Jan Henrik, Rosland, Kjell, Hole   +4 more
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The orofacial formalin test in rats: effects of different formalin concentrations

Pain, 1995
In this study of the orofacial formalin test in rats, the effects of different formalin concentrations (0.2%, 0.5%, 1.5%, 2.5%, 5% and 10%) on the behavioural nociceptive response (face rubbing) was investigated. The histological responses of the skin were also evaluated.
Pierre, Clavelou, Radhouane, Dallel, Thierry, Orliaguet, Alain, Woda, Patrick, Raboisson   +4 more
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Electroencephalographic responses to the formalin test in rats

Pain, 1999
The formalin test is an animal model of persistent pain. Although biphasic behavioral responses to formalin injection have been well described, the significance of the biphasic time course of the pain behaviors has not been established. To explore the significance of the behavioral responses to the formalin injection, we measured and analyzed cortical ...
F, Ichinose, M, Miyazaki, T, Goto, H, Takahashi, K, Terui, Y, Niimi, S, Uezono, S, Morita, H, Yanagida   +8 more
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Effect of Picrotoxin on Antinociception in the Formalin Test

Pharmacology & Toxicology, 1996
Abstract: Subcutaneous injection of diluted formalin (0.25 μl of 0.5%) caused a biphasic pain response in mice. The first phase of pain was observed during the first 5 min., while the second phase occurred 10‐30 min. after formalin administration.
M R, Heidari, F, Khalili, M, Ghazi-khansari, B, Hashemi, M R, Zarrindast   +4 more
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Antinociceptive effect of gabapentin in the formalin test

Methods and Findings in Experimental and Clinical Pharmacology, 1999
Gabapentin is an adjunctive drug for the treatment of resistant partial seizures. The antinociceptive effect of this drug was assessed by using the formalin pain test in rats. Although low dose gabapentin (10 mg/kg s.c.) was unable to alter pain scores, higher doses (30 and 90 mg/kg s.c.) significantly reduced them.
R, Dixit, V K, Bhargava, N, Kaur
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ON THE MECHANISM OF CARBAMAZEPIN-INDUCED ANTINOCICEPTION IN THE FORMALIN TEST

International Journal of Neuroscience, 2006
In the present study, the effect of lidocaine (a sodium channel blocker) on carbamazepine-induced antinociception, in formalin test was investigated. Intraperitoneal (i.p.) administration of different doses of carbamazepine (3.5, 7, 15, and 30 mg/kg) induced a dose-dependent antinociception in mice, in the first and second phases of the test. Different
Mousa, Sahebgharani, Ahmad Abdi, Hossein-Abad, M R, Zarrindast   +2 more
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Sildenafil increases diclofenac antinociception in the formalin test

European Journal of Pharmacology, 2001
The antinociceptive activity of an inhibitor of phosphodiesterase 5, alone or combined with diclofenac, was assessed in the formalin test. Local administration of diclofenac produced a significant antinociception in both phases of the formalin test in female Wistar rats. In contrast, 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [3,4-d]
R, Asomoza-Espinosa, R, Alonso-López, T, Mixcoatl-Zecuatl, P, Aguirre-Bañuelos, J E, Torres-López, V, Granados-Soto   +5 more
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d-Methadone Is Antinociceptive in the Rat Formalin Test

The Journal of Pharmacology and Experimental Therapeutics, 1997
The l-isomer of methadone possesses opioid activity, whereas the d-isomer is weak or inactive as an opioid. Both d- and l-methadone have been shown to bind to the N-methyl-D-aspartate (NMDA) receptor. To determine whether d-methadone has functional, in vivo NMDA receptor antagonist activity, the antinociceptive effects of d-methadone were evaluated in ...
N, Shimoyama, M, Shimoyama, K J, Elliott, C E, Inturrisi   +3 more
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