Results 261 to 270 of about 6,977,566 (297)
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Antinociceptive activity of deltorphin analogs in the formalin test
Life Sciences, 1996Two deltorphin (DLT: Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2) analogs, [N alpha-n-butyl-Gly6]DLT ([nBuG6]DLT) and [N alpha-iso-butyl-Gly6]DLT ([isoBuG6]DLT), were examined for their antinociceptive activities by a formalin test in mice after subcutaneous (s.c.) injection.
T, Chiba, H, Murase, A, Ambo, Y, Sasaki
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The development of opioid tolerance in the formalin test in the rat
Pain, 1995The formalin test produces persistent pain in animals and is believed to provide a better model of the pain experienced by humans than do tests that measure reflex nociceptive thresholds. The present study evaluated whether tolerance to morphine develops in the formalin test in the rat.
Dawn J, Detweiler +2 more
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Peripheral Synergism between Tramadol and Ibuprofen in the Formalin Test
Drug Development Research, 2014Abstract Preclinical Research Analgesics with different mechanisms of action can be combined in order to obtain pharmacological synergism, employing lower doses of each agent, thus diminishing side effects. For instance, an atypical dual analgesic such as tramadol (TMD) and a nonsteroidal anti‐inflammatory drug such as ibuprofen (IBU) are good
Chavarria Bolanos, Daniel +3 more
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Estradiol Replacement in Ovariectomized Rats Is Antihyperalgesic in the Formalin Test
The Journal of Pain, 2007A subcutaneous implant of 17beta-estradiol or progesterone provides steady-state serum hormone levels from 7 to 24 days after implantation and allows the evaluation of the effects of the replacement with these hormones on phase 1 and phase 2 formalin-induced behaviors in ovariectomized (OVX) rats.
Mannino, Christy A. +3 more
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The formalin test in mice: the influence of ambient temperature
Pain, 1991The ambient temperature had a confounding influence on the licking response in the formalin test. No effect was demonstrated in the early phase. In the late phase, the licking activity was much lower at 20 degrees C than at 25 degrees C. Both the intensity and the duration of the response were increased by increasing the ambient temperature from 20 ...
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Imipramine-Induced Antinociception in the Formalin Test
Pharmacology, 2003This study concerned the effect of swim stress on imipramine-induced antinociception in mice. The data showed that intraperitoneal (i.p.) administration of different doses of imipramine (10–40 mg/kg) and 0.5–3 min of swim stress (17°C) induced antinociception in the first and second phases of the formalin test. Low period of swim stress (10 s) with low
Mohammad-Reza Zarrindast +2 more
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Stability of formalin test solutions
Contact Dermatitis, 1981J E, Wahlberg, E, Kartus
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Scoring properties of the formalin test in the mouse
1997A large number of behavioural methods have been developed to investigate nociception and the actions of analgesic drugs in animals. The formalin test is increasingly used as a model of injury-produced pain. The generally accepted method of rating pain used for mice is to count or time paw licks.
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Nociceptive Properties of Aminoguanidine in the Rat Formalin Test
Regional Anesthesia & Pain Medicine, 1999M-F Doursout, E. Davidson, J. E. Chelly
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