Results 101 to 110 of about 9,358 (215)

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Characterization of a novel thermostable NAD+-dependent formate dehydrogenase from Methylacidiphilum kamchatkense Kam1 (MkaFDH)

Current Research in Biotechnology
Metal-independent NAD+-dependent formate dehydrogenases (FDHs) are enzymes responsible for catalyzing the conversion of formate (HCOO–) to carbon dioxide (CO2), a biological reaction involved in microbial carbon processing and cofactor regeneration ...
Khouloud Zribi, Matteo Ciciani, Agata Sofia Assunção Carreira, Martina Paganin, Sara Pozzo, Lucio Cinà, Baris Binay, Francesco Secundo, Nicola Segata, Alessandro Provenzani   +9 more
doaj   +1 more source

Novel copper-containing membrane monooxygenases (CuMMOs) encoded by alkane-utilizing Betaproteobacteria. [PDF]

, 2020
Copper-containing membrane monooxygenases (CuMMOs) are encoded by xmoCAB(D) gene clusters and catalyze the oxidation of methane, ammonia, or some short-chain alkanes and alkenes.
Dunfield, Peter F, Khadka, Roshan, Kwon, Miye, Lopez-Jauregui, Azriel Abraham, Malmstrom, Rex R, Rochman, Fauziah F, Sheremet, Andriy, Tamas, Ivica, V Smirnova, Angela, Verbeke, Tobin J, Woyke, Tanja, Yoon, Sukhwan   +11 more
core   +1 more source

Efficient hydrogen‐dependent carbon dioxide reduction by Escherichia coli. [PDF]

, 2018
Hydrogen‐dependent reduction of carbon dioxide to formic acid offers a promising route to greenhouse gas sequestration; carbon abatement technologies; hydrogen transport and storage; and the sustainable generation of renewable chemical feedstocks [1 ...
Alissandratos, Appel, Aresta, Bassegoda, Begg, Carroll, Casadaban, Ceccaldi, Choi, Frank Sargent, Fraser Brown, Gregg, Jens, Kamm, Lopes, Lv, Lü, Lüke, Maeda, Magali Roger, Maia, McDowall, Nicholls, Niks, Nitschke, Padan, Peters, Pinske, Reeve, Renon, Sargent, Sawers, Sawers, Sawers, Schlindwein, Schuchmann, Thauer, Waight, Wang, Wiechert, William Gabrielli, Woods, Yishai, Yishai, Yu, Zelcbuch   +45 more
core   +2 more sources

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Molecular Electrocatalyst Enables Direct Electrochemical Capture and Conversion of CO2 up to Atmospheric Concentration

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
A molecular manganese electrocatalyst enables the direct electrochemical capture and conversion of dilute CO2 (1% – 0.2%) to CO with nearly unit Faradaic efficiency, achieving high efficiency even at atmospheric concentrations (420 ppm). By bypassing energy‐intensive pre‐concentration steps, this integrated approach highlights a sustainable pathway for
Mattia Vettori, Federico Franco, Sergio Fernández, Guillem Pey, Vlad Martin Diaconescu, Josep M. Luis, Julio Lloret‐Fillol   +6 more
wiley   +2 more sources

Extracellular Enzymes Facilitate Electron Uptake in Biocorrosion and Bioelectrosynthesis

mBio, 2015
Direct, mediator-free transfer of electrons between a microbial cell and a solid phase in its surrounding environment has been suggested to be a widespread and ecologically significant process.
Jörg S. Deutzmann, Merve Sahin, Alfred M. Spormann   +2 more
doaj   +1 more source

Comparative genomics in acid mine drainage biofilm communities reveals metabolic and structural differentiation of co-occurring archaea [PDF]

, 2016
Background Metal sulfide mineral dissolution during bioleaching and acid mine drainage (AMD) formation creates an environment that is inhospitable to most life. Despite dominance by a small number of bacteria, AMD microbial biofilm communities contain a
Banfield, Jillian F., Castelle, Cindy, Comolli, Luis R., Denef, Vincent J., Justice, Nicholas B., Thomas, Brian C., Yelton, Alexis P.   +6 more
core   +2 more sources

Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources

The FEBS Journal, EarlyView.
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani, Marco Gargiulo, Elia Lio, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Maria Assunta Chiacchio, Barış Binay, Stefania Brocca, Francesco Secundo   +8 more
wiley   +1 more source