Results 131 to 140 of about 6,524,554 (346)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Robust Formation Control for Unmanned Ground Vehicles Using Onboard Visual Sensors and Machine Learning

Drones
The performance of unmanned ground vehicle (UGV) formation is crucial for large-scale material transport. In a non-communicative environment, visual perception plays a central role in formation control. However, due to unstable lighting conditions, dust,
Mingfei Li, Haibin Liu, Feng Xie
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

CONCO2 RANDOMIZED CONTROLLED TRIAL INTERIM UPDATE: EMBRYO CULTURE IN A CONTINUOUS CARBON DIOXIDE SETTING DOES NOT NEGATIVELY IMPACT BLASTOCYST FORMATION RATES [PDF]

, 2021
Julia G. Kim, Cindy Comito, Rosanna Pangasnan, Brent M. Hanson, Amber M. Klimczak, Nola S. Herlihy, Kathleen H. Hong, Emre Seli, Richard T. Scott   +8 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Consensus-Based Formation Control and Gyroscopic Obstacle Avoidance for Multiple Autonomous Underwater Vehicles on SE(3)

Journal of Marine Science and Engineering
To address the control challenges posed by increasingly complex mission scenarios, this paper aims to develop an advanced formation control and obstacle avoidance strategy for autonomous underwater vehicles (AUVs) in SE(3).
Qingzhe Zhen, Lei Wan, Yuansheng Zhang, Dapeng Jiang   +3 more
doaj   +1 more source

A platoon based model for urban traffic networks: identification, modeling and distributed control [PDF]

, 2009
Urban traffic control poses a challenging problem in terms of coordinating the different traffic lights that can be used in order to influence the traffic flow.
Boel, René, Marinica, Nicolae-Emanuel
core   +1 more source

The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation [PDF]

, 2021
Minsu Lee, Mika Higashide, Hyung-Seok Choi, Ke Li, Soogil Hong, Kangseok Lee, Akira Shinohara, Miki Shinohara, Keun Pil Kim   +8 more
openalex   +1 more source

Formation-Controlled Dimensionality Reduction

CoRR
Dimensionality reduction represents the process of generating a low dimensional representation of high dimensional data. Motivated by the formation control of mobile agents, we propose a nonlinear dynamical system for dimensionality reduction. The system consists of two parts; the control of neighbor points, addressing local structures, and the control
Jeong, Taeuk, Jung, Yoon Mo, Lee, Euntack   +2 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source